Emerging findings disclose unexpected components of G protein-coupled receptor (GPCR)
signaling and cell biology. Select GPCRs exhibit classical signaling, that is restricted to cell …

After it was proposed that the osteoblast lineage controlled the formation of osteoclasts, cell
culture methods were developed that established this to be the case. Evidence was …

Summary Vacuolar protein sorting-35 (VPS35) is a retromer component for endosomal
trafficking. Mutations of VPS35 have been linked to familial Parkinson's disease (PD). Here …

Vacuolar protein sorting-35 (VPS35) is essential for endosome-to-Golgi retrieval of
membrane proteins. Mutations in the VPS35 gene have been identified in patients with …

Osteocytes are the most abundant (90% to 95%) cells in bone and have emerged as an
important regulator of hematopoiesis, but their role in neutrophil development and the …

Background Vacuolar protein sorting 35 (VPS35), a key component of retromer, plays an
important role in endosome-to-Golgi retrieval of membrane proteins. Dysfunction of …

Receptor activator of nuclear factor kappa B-ligand (RANKL), its receptor RANK, and
osteoprotegerin which binds RANKL and acts as a soluble decoy receptor, are essential …

Alzheimer's Disease (AD) and osteoporosis are both age-related degenerative diseases.
Many studies indicate that these two diseases share common pathogenesis mechanisms. In …

Background Whether bone mineral density (BMD) is related to the risk of Parkinson's
disease (PD) is unclear. Objectives The objective of this study was to examine the …

Rab27A regulates transport of lysosome-related organelles (LROs) and release of secretory
granules in various types of cells. Here, we identified up-regulation of Rab27A during …