Stress is an essential adaptive response that enables the organism to cope with challenges
and restore homeostasis. Different stressors require distinctive corrective responses in …

Opioid use disorder (OUD) is a major current cause of morbidity and mortality. Long-term
exposure to short-acting opioids (MOP-r agonists such as heroin or fentanyl) results in …

Motivation Seurat is one of the most popular software suites for the analysis of single-cell
RNA sequencing data. Considering the popularity of the tidyverse ecosystem, which offers a …

A primary challenge in single-cell RNA sequencing (scRNA-seq) studies comes from the
massive amount of data and the excess noise level. To address this challenge, we introduce …

Cellular omics such as single-cell genomics, proteomics, and microbiomics allow the
characterization of tissue and microbial community composition, which can be compared …

Single-cell RNA-seq (scRNA-seq) studies have profiled over 100 million human cells across
diseases, developmental stages, and perturbations to date. A singular view of this vast and …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

The opioid epidemic represents a national crisis. Oxycodone is one of the most prescribed
opioid medications in the United States, whereas buprenorphine is currently the most …

Opioids are excellent analgesics for the clinical treatment of various types of acute and
chronic pain, particularly cancer-related pain. Nevertheless, it is well known that opioids …

Of the 12 million people who inject drugs worldwide, 13% live with HIV. Whether opioid use
impacts HIV pathogenesis and latency is an outstanding question. To gain insight into …