Recent progress in machine learning (ML), together with advanced computational power,
have provided new research opportunities in cardiovascular modeling. While classifying …

Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …

Degenerative mitral valve disease is the main cause of primary mitral regurgitation with two
phenotypes: fibroelastic deficiency (FED) often with localized myxomatous degeneration …

Assessment of mitral valve (MV) function is important in many diagnostic, prognostic, and
surgical planning applications for treatment of MV disease. Yet, to date, there are no …

Ischemic mitral regurgitation (IMR) is a currently prevalent disease in the US that is projected
to become increasingly common as the aging population grows. In recent years, image …

Collagen fibers are the primary structural elements that define many soft-tissue structure and
mechanical function relationships, so that quantification of collagen organization is essential …

Cell-shape is a conglomerate of mechanical, chemical, and biological mechanisms that
reflects the cell biophysical state. In a specific application, we consider aortic valve interstitial …

Valve interstitial cells (VIC) are the primary cell type residing within heart valve tissues. In
many valve pathologies, VICs become activated and will subsequently profoundly remodel …

The atrioventricular heart valve (AHV) leaflets have a complex microstructure composed of
four distinct layers: atrialis, ventricularis, fibrosa and spongiosa. Specifically, the spongiosa …

Unidirectional blood flow in the left side of the heart is regulated by the mitral valve. To better
understand the mitral valve function, researchers have examined the structural and …