Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
P Sakornsakolpat, D Prokopenko, M Lamontagne… - Nature …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
[HTML][HTML] Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in …
Background Understanding the genetic basis of airflow obstruction and smoking behaviour
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD) …
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD) …
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function
and is the third leading cause of death globally. Through genome-wide association …
and is the third leading cause of death globally. Through genome-wide association …
Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies
Quantitative traits analyzed in Genome-Wide Association Studies (GWAS) are often
nonnormally distributed. For such traits, association tests based on standard linear …
nonnormally distributed. For such traits, association tests based on standard linear …
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis
Background The genetic risk factors for susceptibility to chronic obstructive pulmonary
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …
Epidemiology of lung cancer
AG Schwartz, ML Cote - Lung cancer and personalized medicine: Current …, 2016 - Springer
Lung cancer continues to be one of the most common causes of cancer death despite
understanding the major cause of the disease: cigarette smoking. Smoking increases lung …
understanding the major cause of the disease: cigarette smoking. Smoking increases lung …
The Rotterdam Study: 2014 objectives and design update
A Hofman, SD Murad, CM van Duijn, OH Franco… - European journal of …, 2013 - Springer
Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …
Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues
E‐cigarette‐derived inhaled nicotine may contribute to the pathogenesis of periodontal and
pulmonary diseases in particular via lung inflammation, injurious, and dysregulated repair …
pulmonary diseases in particular via lung inflammation, injurious, and dysregulated repair …
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
Background Pulmonary function decline is a major contributor to morbidity and mortality
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …