Abstract “Hemichannels” are defined as the halves of gap junction channels (also termed
connexons) that are contributed by one cell;“hemichannels” are considered to be functional …

Gap junctions (GJ), specialised membrane structures that mediate cell-to-cell
communication in almost all animal tissues, are composed of intercellular channel-forming …

Gap junctions form the intercellular pathway for cell-to-cell transmission of the cardiac
impulse from its site of origin, the sinoatrial node, along the atria, the atrioventricular …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

Background—We report that elevated connexin-43 (Cx-43) in stem cells preconditioned with
insulin-like growth factor-1 (IGF-1) is cytoprotective and reprograms the cells for …

Cardiac complications are a common cause of death in individuals with the inherited
multisystemic disease myotonic dystrophy type 1 (DM1). A characteristic molecular feature of …

Background—An estimated 10% to 15% of sudden infant death syndrome (SIDS) cases may
stem from channelopathy-mediated lethal arrhythmias. Loss of the GJA1-encoded gap …

Hemichannels are large pore ion channels that in the traditional view are formed when half
a gap connexin junction opens to the extracellular space. It is now evident that other ion …

As part of the Halifax Project, this review brings attention to the potential effects of
environmental chemicals on important molecular and cellular regulators of the cancer …

Gap junctions are intercellular conduits for small molecules made up by protein subunits
called connexins. A large number of connexin genes were found in mouse and man, and …