Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Metastasis is the leading cause of cancer-associated mortality and the underlying
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …

Macrophages are critical regulators of tissue homeostasis but are also abundant in the
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …

Simple Summary Growth factors are hormone-like molecules able to promote division and
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …

Tumour-associated macrophages (TAMs) are crucial components of the tumour
microenvironment and play a significant role in tumour development and drug resistance by …

Cancer development and progression occurs in concert with alterations in the surrounding
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …

Every year novel biologically active compounds are designed as antitumor agents. This
review covers and highlights some of the most important findings described during 2018 …

Tumor metastasis is a major contributor to the death of cancer patients. It is driven not only
by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between …