Animal models play an indispensable role in the study of human diseases. However, animal
models of different diseases do not fully mimic the complex internal environment of humans …

Effective antiretroviral therapy (ART) blunts viraemia, which enables HIV-1-infected
individuals to control infection and live long, productive lives. However, HIV-1 infection …

Since the late 1980s, mice have been repopulated with human hematopoietic cells to study
the fundamental biology of human hematopoiesis and immunity, as well as a broad range of …

Despite positive testing in animal studies, more than 80% of novel drug candidates fail to
proof their efficacy when tested in humans. This is primarily due to the use of preclinical …

Immunotherapy is at the forefront of cancer treatment. The advent of numerous novel
approaches to cancer immunotherapy, including immune checkpoint antibodies, adoptive …

Introduction and methods In this study we report that sequential treatment of supercharged
NK (sNK) cells with either chemotherapeutic drugs or check-point inhibitors eliminate both …

Animal models of rheumatoid arthritis (RA) are essential for studying the pathogenesis of RA
in vivo and determining the efficacy of anti‑RA drugs. During the past decades, numerous …

Therapeutic role of NK cells in solid tumors was challenged previously even though their
role in hematological malignancies has clearly been established. Furthermore, functions …

High levels of IL1β can result in chronic inflammation, which in turn can promote tumor
growth and metastasis. Inhibition of IL1β could therefore be a promising therapeutic option …

Biomedical advances in vision research have been greatly facilitated by the clinical
accessibility of the visual system, its ease of experimental manipulation, and its ability to be …