The development and improvement of immunodeficient mice and humanized immune system mouse models
J Chen, S Liao, Z Xiao, Q Pan, X Wang… - Frontiers in …, 2022 - frontiersin.org
Animal models play an indispensable role in the study of human diseases. However, animal
models of different diseases do not fully mimic the complex internal environment of humans …
models of different diseases do not fully mimic the complex internal environment of humans …
Eradicating HIV-1 infection: seeking to clear a persistent pathogen
NM Archin, JM Sung, C Garrido… - Nature Reviews …, 2014 - nature.com
Effective antiretroviral therapy (ART) blunts viraemia, which enables HIV-1-infected
individuals to control infection and live long, productive lives. However, HIV-1 infection …
individuals to control infection and live long, productive lives. However, HIV-1 infection …
Building the next generation of humanized hemato-lymphoid system mice
T Martinov, KM McKenna, WH Tan, EJ Collins… - Frontiers in …, 2021 - frontiersin.org
Since the late 1980s, mice have been repopulated with human hematopoietic cells to study
the fundamental biology of human hematopoiesis and immunity, as well as a broad range of …
the fundamental biology of human hematopoiesis and immunity, as well as a broad range of …
Concise review: humanized models of tumor immunology in the 21st century: convergence of cancer research and tissue engineering
BM Holzapfel, F Wagner, L Thibaudeau… - Stem Cells, 2015 - academic.oup.com
Despite positive testing in animal studies, more than 80% of novel drug candidates fail to
proof their efficacy when tested in humans. This is primarily due to the use of preclinical …
proof their efficacy when tested in humans. This is primarily due to the use of preclinical …
Humanized mouse models to evaluate cancer immunotherapeutics
S Guil-Luna, C Sedlik, E Piaggio - Annual Review of Cancer …, 2021 - annualreviews.org
Immunotherapy is at the forefront of cancer treatment. The advent of numerous novel
approaches to cancer immunotherapy, including immune checkpoint antibodies, adoptive …
approaches to cancer immunotherapy, including immune checkpoint antibodies, adoptive …
Sequential therapy with supercharged NK cells with either chemotherapy drug cisplatin or anti-PD-1 antibody decreases the tumor size and significantly enhances the …
Introduction and methods In this study we report that sequential treatment of supercharged
NK (sNK) cells with either chemotherapeutic drugs or check-point inhibitors eliminate both …
NK (sNK) cells with either chemotherapeutic drugs or check-point inhibitors eliminate both …
Applicability and implementation of the collagen‑induced arthritis mouse model, including protocols
J Luan, Z Hu, J Cheng, R Zhang… - Experimental and …, 2021 - spandidos-publications.com
Animal models of rheumatoid arthritis (RA) are essential for studying the pathogenesis of RA
in vivo and determining the efficacy of anti‑RA drugs. During the past decades, numerous …
in vivo and determining the efficacy of anti‑RA drugs. During the past decades, numerous …
Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and …
Therapeutic role of NK cells in solid tumors was challenged previously even though their
role in hematological malignancies has clearly been established. Furthermore, functions …
role in hematological malignancies has clearly been established. Furthermore, functions …
Targeting the IL1β pathway for cancer immunotherapy remodels the tumor microenvironment and enhances antitumor immune responses
R Diwanji, NA O'Brien, JE Choi, B Nguyen… - Cancer Immunology …, 2023 - AACR
High levels of IL1β can result in chronic inflammation, which in turn can promote tumor
growth and metastasis. Inhibition of IL1β could therefore be a promising therapeutic option …
growth and metastasis. Inhibition of IL1β could therefore be a promising therapeutic option …
Developing cellular therapies for retinal degenerative diseases
Biomedical advances in vision research have been greatly facilitated by the clinical
accessibility of the visual system, its ease of experimental manipulation, and its ability to be …
accessibility of the visual system, its ease of experimental manipulation, and its ability to be …