The key players of the chronic kidney disease-mineral and bone disorders (CKD-MBD) are
calcium, phosphate, PTH, FGF23, and the vitamin D hormonal system. The progressive …

Chronic kidney disease (CKD) is associated with the development of mineral bone disorder
(MBD), osteoporosis, and fragility fractures. Among CKD patients, adynamic bone disease or …

Chronic kidney disease (CKD) is a complex and multifactorial disease, and one of the most
prevalent worldwide. Chronic kidney disease–mineral bone disorders (CKD–MBD) with …

Results We included 25 studies to March 31, 2015 with 4770 participants (88% on
hemodialysis). Patients receiving sevelamer had lower all–cause mortality (risk ratio [RR] …

Background Phosphate binders are used to reduce positive phosphate balance and to lower
serum phosphate levels for people with chronic kidney disease (CKD) with the aim to …

It is commonly held that osteitis fibrosa and mixed uremic osteodystrophy are the
predominant forms of renal osteodystrophy in patients with chronic kidney disease. Osteitis …

Hyperphosphatemia, which is nearly universal in kidney failure, is accompanied by low
serum levels of vitamin D and hypocalcemia. Without treatment, severe secondary …

Chronic kidney disease–mineral bone disorder (CKD‐MBD) is defined by abnormalities in
mineral and hormone metabolism, bone histomorphometric changes, and/or the presence of …

Results Serum levels of sclerostin and iPTH correlated negatively. In unadjusted analyses,
sclerostin correlated negatively with histomorphometric parameters of turnover, osteoblastic …

Maintenance of phosphate balance is essential for life, and mammals have developed a
sophisticated system to regulate phosphate homeostasis over the course of evolution …