Recent evidence from omic analysis for redox signalling and mitochondrial oxidative stress in COPD
COPD is driven by exogenous and endogenous oxidative stress derived from inhaled
cigarette smoke, air pollution and reactive oxygen species from dysregulated mitochondria …
cigarette smoke, air pollution and reactive oxygen species from dysregulated mitochondria …
The importance of genomic analysis in cracking the coronavirus pandemic
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
pushed the scientific community to undertake intense research efforts. Understanding SARS …
pushed the scientific community to undertake intense research efforts. Understanding SARS …
Iron in airway macrophages and infective exacerbations of chronic obstructive pulmonary disease
T Ho, M Nichols, G Nair, K Radford, M Kjarsgaard… - Respiratory …, 2022 - Springer
Background Excess pulmonary iron has been implicated in the pathogenesis of lung
disease, including asthma and COPD. An association between higher iron content in …
disease, including asthma and COPD. An association between higher iron content in …
Evaluation of common protein biomarkers involved in the pathogenesis of respiratory diseases with proteomic methods: A systematic review
H Rezaeeyan, M Arabfard, HR Rasouli… - Immunity …, 2023 - Wiley Online Library
Aim Respiratory disease (RD) is one of the most common diseases characterized by lung
dysfunction. Many diagnostic mechanisms have been used to identify the pathogenic agents …
dysfunction. Many diagnostic mechanisms have been used to identify the pathogenic agents …
Non-heme iron overload impairs monocyte to macrophage differentiation via mitochondrial oxidative stress
Iron is a key element for systemic oxygen delivery and cellular energy metabolism. Thus
regulation of systemic and local iron metabolism is key for maintaining energy homeostasis …
regulation of systemic and local iron metabolism is key for maintaining energy homeostasis …
Cigarette smoke particle-induced lung injury and iron homeostasis
AJ Ghio, EN Pavlisko, VL Roggli, NW Todd… - … journal of chronic …, 2022 - Taylor & Francis
It is proposed that the mechanistic basis for non-neoplastic lung injury with cigarette
smoking is a disruption of iron homeostasis in cells after exposure to cigarette smoke …
smoking is a disruption of iron homeostasis in cells after exposure to cigarette smoke …
Red blood cell-derived iron alters macrophage function in COPD
JM Baker, M Hammond, J Dungwa, R Shah… - Biomedicines, 2021 - mdpi.com
Lung macrophage iron levels are increased in COPD patients. Lung macrophage iron levels
are thought to be increased by cigarette smoke, but the role of red blood cells (RBCs) as a …
are thought to be increased by cigarette smoke, but the role of red blood cells (RBCs) as a …
Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease
Nutritional immunity is the sequestration of bioavailable trace metals such as iron, zinc and
copper by the host to limit pathogenicity by invading microorganisms. As one of the most …
copper by the host to limit pathogenicity by invading microorganisms. As one of the most …
Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD
L Faherty, S Kenny, SM Cloonan - Clinical Science, 2023 - portlandpress.com
Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease characterised
by airflow limitation, chronic bronchitis, emphysema and airway remodelling. Cigarette …
by airflow limitation, chronic bronchitis, emphysema and airway remodelling. Cigarette …
Hepcidin is essential for alveolar macrophage function and is disrupted by smoke in a murine chronic obstructive pulmonary disease model
Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease associated
with cigarette smoking. Alterations in local lung and systemic iron regulation are associated …
with cigarette smoking. Alterations in local lung and systemic iron regulation are associated …