[HTML][HTML] Translocator protein-18 kDa (TSPO) positron emission tomography (PET) imaging and its clinical impact in neurodegenerative diseases
AC Dupont, B Largeau, MJ Santiago Ribeiro… - International journal of …, 2017 - mdpi.com
In vivo exploration of activated microglia in neurodegenerative diseases is achievable by
Positron Emission Tomography (PET) imaging, using dedicated radiopharmaceuticals …
Positron Emission Tomography (PET) imaging, using dedicated radiopharmaceuticals …
[HTML][HTML] TSPO imaging in animal models of brain diseases
N Van Camp, S Lavisse, P Roost, F Gubinelli… - European Journal of …, 2021 - Springer
Over the last 30 years, the 18-kDa TSPO protein has been considered as the PET imaging
biomarker of reference to measure increased neuroinflammation. Generally assumed to …
biomarker of reference to measure increased neuroinflammation. Generally assumed to …
18F-FSPG PET/CT Imaging of System xC– Transporter Activity in Patients with Primary and Metastatic Brain Tumors
Background The PET tracer (4S)-4-(3-[18F] fluoropropyl)-l-glutamate (18F-FSPG) targets the
system xC–cotransporter, which is overexpressed in various tumors. Purpose To assess the …
system xC–cotransporter, which is overexpressed in various tumors. Purpose To assess the …
[HTML][HTML] Is System xc− a Suitable Target for Tumour Detection and Response Assessment with Imaging?
Simple Summary The expression of the cysteine–glutamate cotransporter, system xc−, is
increased in cancer cells across many cancer types. Imaging system xc− provides new …
increased in cancer cells across many cancer types. Imaging system xc− provides new …
Inflammation in stroke: the role of cholinergic, purinergic and glutamatergic signaling
The inflammatory response is a major factor in stroke pathophysiology and contributes to
secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent …
secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent …
[HTML][HTML] The role of advanced magnetic resonance imaging techniques in multiple sclerosis clinical trials
KR Mahajan, D Ontaneda - Neurotherapeutics, 2017 - Elsevier
Magnetic resonance imaging has been crucial in the development of anti-inflammatory
disease-modifying treatments. The current landscape of multiple sclerosis clinical trials is …
disease-modifying treatments. The current landscape of multiple sclerosis clinical trials is …
[HTML][HTML] PET imaging with [18F] FSPG evidences the role of system xc-on brain inflammation following cerebral ischemia in rats
Abstract In vivo Positron Emission Tomography (PET) imaging of the cystine-glutamate
antiporter (system xc-) activity with [18 F] FSPG is meant to be an attractive tool for the …
antiporter (system xc-) activity with [18 F] FSPG is meant to be an attractive tool for the …
[HTML][HTML] Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study
S Yamagishi, Y Iga, M Nakamura, C Takizawa… - Journal of …, 2019 - Springer
Background Microglial cells are activated in response to changes in brain homeostasis
during aging, dementia, and stroke. Type 2 endocannabinoid receptors (CB2) and …
during aging, dementia, and stroke. Type 2 endocannabinoid receptors (CB2) and …
[HTML][HTML] In vivo imaging of CNS microglial activation/macrophage infiltration with combined [18F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting …
Purpose To evaluate the feasibility and sensitivity of multimodality PET/CT and MRI imaging
for non-invasive characterization of brain microglial/macrophage activation occurring during …
for non-invasive characterization of brain microglial/macrophage activation occurring during …
[HTML][HTML] Molecular imaging of immune cell dynamics during de-and remyelination in the cuprizone model of multiple sclerosis by [18F] DPA-714 PET and MRI
Background: Activation and dysregulation of innate, adaptive and resident immune cells in
response to damage determine the pathophysiology of demyelinating disorders. Among the …
response to damage determine the pathophysiology of demyelinating disorders. Among the …