Alternative mRNA transcription, processing, and translation: insights from RNA sequencing
E de Klerk, P AC't Hoen - Trends in Genetics, 2015 - cell.com
The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …
Alternative polyadenylation: methods, findings, and impacts
W Chen, Q Jia, Y Song, H Fu, G Wei… - Genomics, Proteomics …, 2017 - academic.oup.com
Alternative polyadenylation (APA), a phenomenon that RNA molecules with different 3′
ends originate from distinct polyadenylation sites of a single gene, is emerging as a …
ends originate from distinct polyadenylation sites of a single gene, is emerging as a …
[HTML][HTML] A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
The rat has been used extensively as a model for evaluating chemical toxicities and for
understanding drug mechanisms. However, its transcriptome across multiple organs, or …
understanding drug mechanisms. However, its transcriptome across multiple organs, or …
QAPA: a new method for the systematic analysis of alternative polyadenylation from RNA-seq data
Alternative polyadenylation (APA) affects most mammalian genes. The genome-wide
investigation of APA has been hampered by an inability to reliably profile it using …
investigation of APA has been hampered by an inability to reliably profile it using …
A survey on methods for predicting polyadenylation sites from DNA sequences, bulk RNA-seq, and single-cell RNA-seq
Alternative polyadenylation (APA) plays important roles in modulating mRNA stability,
translation, and subcellular localization, and contributes extensively to shaping eukaryotic …
translation, and subcellular localization, and contributes extensively to shaping eukaryotic …
APADB: a database for alternative polyadenylation and microRNA regulation events
S Müller, L Rycak, F Afonso-Grunz, P Winter… - Database, 2014 - academic.oup.com
Alternative polyadenylation (APA) is a widespread mechanism that contributes to the
sophisticated dynamics of gene regulation. Approximately 50% of all protein-coding human …
sophisticated dynamics of gene regulation. Approximately 50% of all protein-coding human …
DeepPASTA: deep neural network based polyadenylation site analysis
Motivation Alternative polyadenylation (polyA) sites near the 3′ end of a pre-mRNA create
multiple mRNA transcripts with different 3′ untranslated regions (3′ UTRs). The sequence …
multiple mRNA transcripts with different 3′ untranslated regions (3′ UTRs). The sequence …
Inference of the human polyadenylation code
Motivation Processing of transcripts at the 3′-end involves cleavage at a polyadenylation
site followed by the addition of a poly (A)-tail. By selecting which site is cleaved, the process …
site followed by the addition of a poly (A)-tail. By selecting which site is cleaved, the process …
A viral genome landscape of RNA polyadenylation from KSHV latent to lytic infection
V Majerciak, T Ni, W Yang, B Meng, J Zhu… - PLoS …, 2013 - journals.plos.org
RNA polyadenylation (pA) is one of the major steps in regulation of gene expression at the
posttranscriptional level. In this report, a genome landscape of pA sites of viral transcripts in …
posttranscriptional level. In this report, a genome landscape of pA sites of viral transcripts in …
Genome-wide identification and predictive modeling of polyadenylation sites in eukaryotes
Abstract Polyadenylation [poly (A)] is a vital step in post-transcriptional processing of pre-
mRNA. Alternative polyadenylation is a widespread mechanism of regulating gene …
mRNA. Alternative polyadenylation is a widespread mechanism of regulating gene …