Plasmodium parasites have a complex life cycle alternating between a mosquito and a
vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium …

The intracellular development and differentiation of the Plasmodium parasite in the host liver
is a prerequisite for the actual onset of malaria disease pathology. Since liver-stage infection …

Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must
navigate the host skin and vasculature to infect the liver. This journey requires distinct …

Plasmodium falciparum and Plasmodium vivax cause the majority of human malaria cases.
Research efforts predominantly focus on P. falciparum because of the clinical severity of …

During macroautophagy, the Atg8 protein is conjugated to phosphatidylethanolamine (PE)
in autophagic membranes. In Apicomplexan parasites, two cysteine proteases, Atg4 and …

Malaria parasites transmitted by mosquito bite are remarkably efficient in establishing
human infections. The infection process requires roughly 30 minutes and is highly complex …

Plasmodium vivax pre-erythrocytic (PE) vaccine research has lagged far behind efforts to
develop Plasmodium falciparum vaccines. There is a critical gap in our knowledge of PE …

Background Plasmodium vivax sporozoites reside in the salivary glands of a mosquito
before infecting a human host and causing malaria. Previous transcriptome-wide studies in …

Plasmodium sporozoites invade hepatocytes, transform into liver stages, and replicate into
thousands of merozoites that infect erythrocytes and cause malaria. Proteins secreted from …

Merosome development is a very important part of the Plasmodium life cycle. It constitutes
the last step of liver stage development after which merozoites egress to the bloodstream …