DNA methylation and gene function

A Razin, AD Riggs - Science, 1980 - science.org
In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of
many cytosine residues to 5-methylcytosine. For several years, control of gene activity by …

DNA methylation

R Singal, GD Ginder - Blood, The Journal of the American …, 1999 - ashpublications.org
SINCE ITS FIRST recognition in 1948, the fifth base of human DNA, 5-methylcytosine (5-mC)
has generated much interest and considerable controversy during attempts to understand its …

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

E Li, TH Bestor, R Jaenisch - Cell, 1992 - Elsevier
Gene targeting in embryonic stem (ES) cells has been used to mutate the murine DNA
methyltransferase gene. ES cell lines homozygous for the mutation were generated by …

[图书][B] Chromatin

KE Van Holde - 2012 - books.google.com
Contemporary views on the structure and function of chromatin are presented and the
history of the development of these ideas as well as the nature of the nucleic acid and …

A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA

A Bird, M Taggart, M Frommer, OJ Miller, D Macleod - Cell, 1985 - cell.com
About 1% of the mouse genome is cleaved by Hpa II to give a discrete fraction on gels. The
nonmethylated fraction is present in all tested tissues, including sperm, and contains Hpa II …

Perspective: transposable elements, parasitic DNA, and genome evolution

MG Kidwell, DR Lisch - Evolution, 2001 - Wiley Online Library
The nature of the role played by mobile elements in host genome evolution is reassessed
considering numerous recent developments in many areas of biology. It is argued that easy …

Repeat-induced gene silencing in mammals

D Garrick, S Fiering, DIK Martin, E Whitelaw - Nature genetics, 1998 - nature.com
In both plants1–3 and Drosophila melanogastei4, 5. expression from a transgenic locus may
be silenced when repeated trans-gene copies are arranged as a concatameric array. This …

DNA methylation in Drosophila melanogaster

F Lyko, BH Ramsahoye, R Jaenisch - Nature, 2000 - nature.com
Certain cytosine residues of eukaryotic DNA are methylated in inactive regions of the
genome. For a long time the fruitfly Drosophila was thought to be an exception,,,, but now the …

[PDF][PDF] Position effects on eukaryotic gene expression

C Wilson, HJ Bellen, WJ Gehring - Annual review of cell biology, 1990 - researchgate.net
Scientists have known for many years that the expression of a euka ryotic gene can be
affected by its chromosomal position (see Sturtevant 1925; Dobzhansky 1936; Lewis 1950) …

CpG islands as gene markers in the vertebrate nucleus

AP Bird - Trends in Genetics, 1987 - cell.com
Methylated and non. methylated DNA sequences coexist in many animal gems. In
vertebrates most of the genome is methylated, and non. methylated sequences are reduced …