The characteristics of the primary tumor blood vessels and the tumor microenvironment drive
the enhanced permeability and retention (EPR) effect, which confers an advantage towards …

Simple Summary Persistent activation of STAT3 is frequently observed in non-small cell lung
cancer and is associated with a poor prognosis. Given the multifaceted role of STAT3 …

Given the long-term ineffectiveness of current therapies and late-stage diagnoses, lung
cancer is a leading cause of malignant diseases. Tumor progression is influenced by cancer …

Non-small cell lung cancer (NSCLC) is a leading cause of cancer death. Tumor progression
depends on interactions of cancer cells with the tumor microenvironment. Here, we find …

Simple Summary With the mortality rate of pancreatic cancer predicted to rise over the
coming years, it is essential that effective treatment strategies are developed as soon as …

Simple Summary The extracellular matrix surrounding or infiltrating tumor tissues, tumor
cells, endothelial cells, immune cells, fibroblasts, macrophages, as well as soluble …

Non‑small cell lung cancer (NSCLC) accounts for over 80% of all diagnosed lung cancer
cases. Lung cancer is the leading cause of cancer‑related deaths worldwide. Most NSCLC …

Lung malignancies accounted for 11% of cancers worldwide in 2020 and remained the
leading cause of cancer deaths. About 80% of lung cancers belong to non-small cell lung …

Highlights•Invasion and metastases are central features of cancer malignancy and constitute
the primary cause of death for> 90% of patients with cancer.•The establishment of effective …

Angiogenesis is a biological process that involves the formation of new blood vessels from
the existing vasculature, and it plays a fundamental role in the development and progression …