The enormous diversity of cell types that characterizes any animal nervous system is defined
by neuron-type-specific gene batteries that endow cells with distinct anatomical and …

Highlights•Terminal selector control terminal steps of neuronal identity acquisition.•Terminal
selectors establish and maintain neuron type-specific identity features.•Terminal selectors …

It is not known at present whether neuronal cell-type diversity—defined by cell-type-specific
anatomical, biophysical, functional and molecular signatures—can be reduced to relatively …

The classification of neurons into distinct types reveals hierarchical taxonomic relationships
that reflect the extent of similarity between neuronal cell types. At the base of such …

Motor neurons (MNs) constitute an ancient cell type targeted by multiple adult-onset
diseases. It is therefore important to define the molecular makeup of adult MNs in animal …

The large diversity of cell types in nervous systems presents a challenge in identifying the
genetic mechanisms that encode it. Here, we report that nearly 200 distinct neurons in the …

Homeobox genes are prominent regulators of neuronal identity, but the extent to which their
function has been probed in animal nervous systems remains limited. In the nematode …

AT-rich interaction domain 3 (ARID3) transcription factors are expressed in the nervous
system, but their mechanisms of action are largely unknown. Here, we provide, in vivo, a …

The phylotranscriptomic analysis of development in several species revealed the expression
of older and more conserved genes in midembryonic stages and younger and more …

Neurons are remarkably long-lived, non-dividing cells that must maintain their functional
features (eg, electrical properties, chemical signaling) for extended periods of time–decades …