The Fanconi anaemia pathway repairs DNA interstrand crosslinks (ICLs) in the genome. Our
understanding of this complex pathway is still evolving, as new components continue to be …

Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …

Replication fork reversal safeguards genome integrity as a replication stress response. DNA
translocases and the RAD51 recombinase catalyze reversal. However, it remains unknown …

Fanconi anemia is a genetic disorder that is characterized by bone marrow failure, as well
as a predisposition to malignancies including leukemia and squamous cell carcinoma …

Extensive tumour inflammation, which is reflected by high levels of infiltrating T cells and
interferon-γ (IFNγ) signalling, improves the response of patients with melanoma to …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

Tubulin is subjected to a number of posttranslational modifications to generate
heterogeneous microtubules. The modifications include removal and ligation of the C …

The WD40-containing E3 ubiquitin ligase RFWD3 has been recently linked to the repair of
DNA damage by homologous recombination (HR). Here we have shown that an RFWD3 …

PARP inhibitors represent a major breakthrough in ovarian cancer care. Almost half of all
ovarian cancers have deficiencies in the homologous recombination (HR) DNA repair …

Homologous recombination (HR) is a highly accurate DNA repair mechanism. Several HR
genes are established cancer susceptibility genes with clinically actionable pathogenic …