Autosomal-recessive cerebellar ataxias (ARCAs) comprise a heterogeneous group of rare
degenerative and metabolic genetic diseases that share the hallmark of progressive …

Mitochondrial diseases are a heterogeneous group of inherited or acquired devastating
disorders that affect the energy metabolism of the body. Many strategies have been …

Cerebellar and afferent ataxias present with a characteristic gait disorder that reflects
cerebellar motor dysfunction and sensory loss. These disorders are a diagnostic challenge …

Mitochondrial dysfunction and oxidative damage are at the origin of numerous
neurodegenerative diseases like Friedreich ataxia and Alzheimer and Parkinson diseases …

Cerebellar ataxias : Current Opinion in Neurology Cerebellar ataxias : Current Opinion in
Neurology Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts …

Friedreich's ataxia (FRDA) is an autosomal recessive inherited disorder characterized by
progressive gait and limb ataxia, dysarthria, areflexia, loss of vibratory and position sense …

Friedreich ataxia (FRDA) is an inherited neurodegenerative disorder caused by GAA repeat
expansion within the FXN gene, leading to epigenetic changes and heterochromatin …

Friedreich ataxia (FRDA), the most common inherited ataxia, is caused by transcriptional
silencing of the nuclear FXN gene, encoding the essential mitochondrial protein frataxin …

Erythropoietin (Epo) has been thought to act exclusively on erythroid progenitor cells. The
identification of Epo receptor (EpoR) in non-haematopoietic cells and tissues including …

Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by
reduced amounts of the mitochondrial protein frataxin. Frataxin levels in research studies …