Inflammasomes in neurological disorders—mechanisms and therapeutic potential

KA Ravichandran, MT Heneka - Nature Reviews Neurology, 2024 - nature.com
Inflammasomes are molecular scaffolds that are activated by damage-associated and
pathogen-associated molecular patterns and form a key element of innate immune …

Blood and cerebrospinal fluid biomarkers of inflammation in Parkinson's disease

M Zimmermann, K Brockmann - Journal of Parkinson's …, 2022 - content.iospress.com
Given the clear role of inflammation in the pathogenesis of Parkinson's disease (PD) and its
impact on incidence and phenotypical characteristics, this review provides an overview with …

Seven mysteries of LAG-3: a multi-faceted immune receptor of increasing complexity

SEA Burnell, L Capitani, BJ MacLachlan… - Immunotherapy …, 2022 - academic.oup.com
Despite three decades of research to its name and increasing interest in immunotherapies
that target it, LAG-3 remains an elusive co-inhibitory receptor in comparison to the well …

Blood biomarkers in patients with Parkinson's disease: a review in context of anesthetic care

J Joo, J Jeong, HJ Park - Diagnostics, 2023 - mdpi.com
Parkinson's disease (PD) is the second most common inflammatory neurodegenerative
disorder after dementia. Preclinical and epidemiological data strongly suggest that chronic …

Inflammation, autoimmunity and neurodegenerative diseases, therapeutics and beyond

JV Garmendia, CV De Sanctis, V Das… - Current …, 2024 - benthamdirect.com
Neurodegenerative disease (ND) incidence has recently increased due to improved life
expectancy. Alzheimer's (AD) or Parkinson's disease (PD) are the most prevalent NDs. Both …

The role of cytotoxic T-lymphocyte antigen 4 in the pathogenesis of multiple sclerosis

MS Basile, P Bramanti, E Mazzon - Genes, 2022 - mdpi.com
Multiple sclerosis (MS) is an autoimmune neurodegenerative disorder of the central nervous
system that presents heterogeneous clinical manifestations and course. It has been shown …

Novel inflammasome and oxidative modulators in Parkinson's disease: a prospective study

A Roy, R Banerjee, S Choudhury, K Chatterjee… - Neuroscience …, 2022 - Elsevier
Abstract Introduction The etiopathogenesis of Parkinson's disease (PD) is not clear. Yet, it
seems likely that inflammation as well as oxidative stress plays a major role in the disease …

Immune Regulation Patterns in Response to Environmental Pollutant Chromate Exposure-Related Genetic Damage: A Cross-Sectional Study Applying Machine …

Z Su, Y Zhang, S Hong, Q Zhang, Z Ji… - Environmental …, 2024 - ACS Publications
Exposure to hexavalent chromium damages genetic materials like DNA and chromosomes,
further elevating cancer risk, yet research rarely focuses on related immunological …

Levodopa-induced Dyskinesia in Parkinson's Disease: Plausible Inflammatory and Oxidative Stress Biomarkers

S Sarkar, A Roy, S Choudhury, R Banerjee… - Canadian Journal of …, 2024 - cambridge.org
Background: Pathophysiology of levodopa-induced dyskinesia (LID) remains obscure.
Increased dopamine metabolism due to prolonged levodopa treatment can exacerbate …

Association between LAG3/CD4 gene variants and risk of Parkinson's disease

E García‐Martín, P Pastor… - European Journal of …, 2022 - Wiley Online Library
Abstract Background/Objectives Several recent studies suggest a possible role of
lymphocyte activation 3 (LAG3) protein. LAG3 can behave as an α‐synuclein ligand, and …