Apple snails are one of the most survived fresh water invasive species that causes massive
economic loss to vegetations, especially to the rice fields. They survive against many …

Phoneutria nigriventer is one of the largest existing true spiders and one of the few
considered medically relevant. Its venom contains several neurotoxic peptides that act on …

This study investigated whether the spinal or systemic treatment with the lipid resolution
mediators resolvin D1 (RvD1), aspirin-triggered resolvin D1 (AT-RvD1) and resolvin D2 …

The treatment with the chemotherapeutic agent paclitaxel produces a painful peripheral
neuropathy, and is associated with an acute pain syndrome in a clinically significant number …

Peripheral inflammation causes mechanical pain behavior and increased action potential
firing. However, most studies examine inflammatory pain at acute, rather than chronic time …

Fibromyalgia (FM) is a complex pathology described as persistent hyperalgesia including
somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still …

Phα1β is a neurotoxin purified from spider venom that acts as a high-voltage-activated
(HVA) calcium channel blocker. This spider peptide has shown a high selectivity for N-type …

The native Phα1β–a Voltage-Gated Calcium Channel (VGCC) blocker–and its Recombinant
Version–were both tested in rodent pain models with an intraplantar injections of capsaicin …

This study investigated the effects of intravenous (iv) administration of recombinant Phα1β
toxin, pregabalin, and diclofenac by the intrathecal route using an animal model …

The venom of the Brazilian armed spider Phoneutria nigriventer is a rich source of
biologically active peptides that have potential as analgesic drugs. In this study, we …