Studying non-covalent drug–DNA interactions
Drug–DNA interactions have been extensively studied in the recent past. Various
techniques have been employed to decipher these interactions. DNA is a major target for a …
techniques have been employed to decipher these interactions. DNA is a major target for a …
Multi-spectroscopic and molecular modelling studies on the interaction of esculetin with calf thymus DNA
Understanding the interaction of small molecules with DNA has become an active research
area at the interface between chemistry, molecular biology and medicine. Plant derived …
area at the interface between chemistry, molecular biology and medicine. Plant derived …
Exploring the binding mechanism of β-resorcylic acid with calf thymus DNA: Insights from multi-spectroscopic, thermodynamic and bioinformatics approaches
Abstract β-resorcylic acid (BR) is a phytochemical which is widely used in the food industry
as a flavouring agent and preservative. It has also been found to exhibit antibacterial action …
as a flavouring agent and preservative. It has also been found to exhibit antibacterial action …
Label-free electrogenerated chemiluminescence aptasensing method for highly sensitive determination of dopamine via target-induced DNA conformational change
D Zhang, M Qian, X Yang, C Zhang, H Qi… - Analytical …, 2023 - ACS Publications
A label-free electrogenerated chemiluminescence (ECL) aptasensing method for highly
sensitive determination of dopamine (DA) was developed based on target-induced DNA …
sensitive determination of dopamine (DA) was developed based on target-induced DNA …
Deciphering the interactions between chlorambucil and calf thymus DNA: a multi-spectroscopic and molecular docking study
Non-covalent interactions of chlorambucil with calf thymus DNA was investigated using multi-
spectroscopic techniques and molecular docking study. Binding constant calculated was …
spectroscopic techniques and molecular docking study. Binding constant calculated was …
Molecular spectroscopic and thermodynamic studies on the interaction of anti-platelet drug ticlopidine with calf thymus DNA
Ticlopidine is an anti-platelet drug which belongs to the thienopyridine structural family and
exerts its effect by functioning as an ADP receptor inhibitor. Ticlopidine inhibits the …
exerts its effect by functioning as an ADP receptor inhibitor. Ticlopidine inhibits the …
In vitro DNA binding studies of therapeutic and prophylactic drug citral
The study of drug-DNA interactions is of great importance, as it paves the way towards the
design of better therapeutic agents. Here, the interaction of DNA with a therapeutic and …
design of better therapeutic agents. Here, the interaction of DNA with a therapeutic and …
Structural-dependent N, O-donor imine-appended Cu (II)/Zn (II) complexes: Synthesis, spectral, and in vitro pharmacological assessment
Four mononuclear bioefficient imine-based coordination complexes,[(L 1) 2 Cu],[(L 1) 2
Zn],[(L 2) Cu (H 2 O)], and [(L 2) Zn (H 2 O)], were synthesized using ligands [L 1= 2-(((3 …
Zn],[(L 2) Cu (H 2 O)], and [(L 2) Zn (H 2 O)], were synthesized using ligands [L 1= 2-(((3 …
Experimental and molecular modelling demonstration of effective DNA and protein binding as well as anticancer potential of two mononuclear Cu (II) and Co (II) …
In the present study, one mononuclear Cu (II)[CuL (SCN)](1) and one mononuclear Co
(II)[CoLN 3](2) complexes, with a Schiff base ligand (HL) formed by condensation of 2 …
(II)[CoLN 3](2) complexes, with a Schiff base ligand (HL) formed by condensation of 2 …
Inclusion complexes of novel formyl chromone Schiff bases with β-Cyclodextrin: Synthesis, characterization, DNA binding studies and in-vitro release study
The present study involved the synthesis of five novel Schiff bases (SB1-SB5) of formyl
chromone and their inclusion complexes with β-cyclodextrin through kneading approach to …
chromone and their inclusion complexes with β-cyclodextrin through kneading approach to …