The medicinal chemistry in the era of machines and automation: recent advances in continuous flow technology

A Gioiello, A Piccinno, AM Lozza… - Journal of medicinal …, 2020 - ACS Publications
Medicinal chemistry plays a fundamental and underlying role in chemical biology,
pharmacology, and medicine to discover safe and efficacious drugs. Small molecule …

Multi‐Step Continuous‐Flow Organic Synthesis: Opportunities and Challenges

J Jiao, W Nie, T Yu, F Yang, Q Zhang… - … A European Journal, 2021 - Wiley Online Library
Continuous‐flow multi‐step synthesis takes the advantages of microchannel flow chemistry
and may transform the conventional multi‐step organic synthesis by using integrated …

Continuous flow chemistry: where are we now? Recent applications, challenges and limitations

FM Akwi, P Watts - Chemical communications, 2018 - pubs.rsc.org
A general outlook of the changing face of chemical synthesis is provided in this article
through recent applications of continuous flow processing in both industry and academia …

High throughput reaction screening using desorption electrospray ionization mass spectrometry

M Wleklinski, BP Loren, CR Ferreira, Z Jaman… - Chemical …, 2018 - pubs.rsc.org
We report the high throughput analysis of reaction mixture arrays using methods and data
handling routines that were originally developed for biological tissue imaging. Desorption …

Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing

P Liu, H Jin, Y Chen, D Wang, H Yan, M Wu… - Chinese Chemical …, 2024 - Elsevier
The pharmaceutical industry is now paying increased attention to continuous manufacturing.
While the revolution to continuous and automated manufacturing is deepening in most of the …

Population balance model enabled digital design and uncertainty analysis framework for continuous crystallization of pharmaceuticals using an automated platform …

Y Barhate, H Kilari, WL Wu, ZK Nagy - Chemical Engineering Science, 2024 - Elsevier
A systematic digital design framework for the development of a digital twin of a continuous
crystallization process was presented using the model compound, diphenhydramine …

Accelerating electrochemical reactions in a voltage‐controlled interfacial microreactor

H Cheng, S Tang, T Yang, S Xu… - Angewandte Chemie …, 2020 - Wiley Online Library
Microdroplet chemistry is attracting increasing attention for accelerated reactions at the
solution–air interface. We report herein a voltage‐controlled interfacial microreactor that …

Over a decade of progress: Crystallization in microfluidic systems

J Jang, WS Kim, TS Seo, BJ Park - Chemical Engineering Journal, 2024 - Elsevier
This review explores recent advancements in microfluidic crystallization that use the synergy
of miniaturization technologies and fluid dynamics to enhance precision and control in …

Chemical reaction monitoring by ambient mass spectrometry

J Sun, Y Yin, W Li, O Jin, N Na - Mass Spectrometry Reviews, 2022 - Wiley Online Library
Chemical reactions conducted in different media (liquid phase, gas phase, or surface) drive
developments of versatile techniques for the detection of intermediates and prediction of …

Rapid on-demand synthesis of lomustine under continuous flow conditions

Z Jaman, TJP Sobreira, A Mufti… - … Process Research & …, 2019 - ACS Publications
Lomustine, an important agent for treatment of brain tumors and Hodgkin's lymphoma, has
been synthesized using continuous flow methodology. Desorption electrospray ionization …