The medicinal chemistry in the era of machines and automation: recent advances in continuous flow technology
A Gioiello, A Piccinno, AM Lozza… - Journal of medicinal …, 2020 - ACS Publications
Medicinal chemistry plays a fundamental and underlying role in chemical biology,
pharmacology, and medicine to discover safe and efficacious drugs. Small molecule …
pharmacology, and medicine to discover safe and efficacious drugs. Small molecule …
Multi‐Step Continuous‐Flow Organic Synthesis: Opportunities and Challenges
J Jiao, W Nie, T Yu, F Yang, Q Zhang… - … A European Journal, 2021 - Wiley Online Library
Continuous‐flow multi‐step synthesis takes the advantages of microchannel flow chemistry
and may transform the conventional multi‐step organic synthesis by using integrated …
and may transform the conventional multi‐step organic synthesis by using integrated …
Continuous flow chemistry: where are we now? Recent applications, challenges and limitations
FM Akwi, P Watts - Chemical communications, 2018 - pubs.rsc.org
A general outlook of the changing face of chemical synthesis is provided in this article
through recent applications of continuous flow processing in both industry and academia …
through recent applications of continuous flow processing in both industry and academia …
High throughput reaction screening using desorption electrospray ionization mass spectrometry
We report the high throughput analysis of reaction mixture arrays using methods and data
handling routines that were originally developed for biological tissue imaging. Desorption …
handling routines that were originally developed for biological tissue imaging. Desorption …
Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing
P Liu, H Jin, Y Chen, D Wang, H Yan, M Wu… - Chinese Chemical …, 2024 - Elsevier
The pharmaceutical industry is now paying increased attention to continuous manufacturing.
While the revolution to continuous and automated manufacturing is deepening in most of the …
While the revolution to continuous and automated manufacturing is deepening in most of the …
Population balance model enabled digital design and uncertainty analysis framework for continuous crystallization of pharmaceuticals using an automated platform …
A systematic digital design framework for the development of a digital twin of a continuous
crystallization process was presented using the model compound, diphenhydramine …
crystallization process was presented using the model compound, diphenhydramine …
Accelerating electrochemical reactions in a voltage‐controlled interfacial microreactor
Microdroplet chemistry is attracting increasing attention for accelerated reactions at the
solution–air interface. We report herein a voltage‐controlled interfacial microreactor that …
solution–air interface. We report herein a voltage‐controlled interfacial microreactor that …
Over a decade of progress: Crystallization in microfluidic systems
This review explores recent advancements in microfluidic crystallization that use the synergy
of miniaturization technologies and fluid dynamics to enhance precision and control in …
of miniaturization technologies and fluid dynamics to enhance precision and control in …
Chemical reaction monitoring by ambient mass spectrometry
J Sun, Y Yin, W Li, O Jin, N Na - Mass Spectrometry Reviews, 2022 - Wiley Online Library
Chemical reactions conducted in different media (liquid phase, gas phase, or surface) drive
developments of versatile techniques for the detection of intermediates and prediction of …
developments of versatile techniques for the detection of intermediates and prediction of …
Rapid on-demand synthesis of lomustine under continuous flow conditions
Z Jaman, TJP Sobreira, A Mufti… - … Process Research & …, 2019 - ACS Publications
Lomustine, an important agent for treatment of brain tumors and Hodgkin's lymphoma, has
been synthesized using continuous flow methodology. Desorption electrospray ionization …
been synthesized using continuous flow methodology. Desorption electrospray ionization …