[HTML][HTML] ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour …
Background Cancers with a defective DNA mismatch repair (dMMR) system contain
thousands of mutations most frequently located in monomorphic microsatellites and are …
thousands of mutations most frequently located in monomorphic microsatellites and are …
Mismatch repair pathway, genome stability and cancer
The acquisition of genomic instability is one of the key characteristics of the cancer cell, and
microsatellite instability (MSI) is an important segment of this phenomenon. This review aims …
microsatellite instability (MSI) is an important segment of this phenomenon. This review aims …
Predictive biomarkers of colon cancer immunotherapy: Present and future
W Hou, C Yi, H Zhu - Frontiers in immunology, 2022 - frontiersin.org
Immunotherapy has revolutionized colon cancer treatment. Immune checkpoint inhibitors
(ICIs) have shown clinical benefits for colon cancer patients, especially those with high …
(ICIs) have shown clinical benefits for colon cancer patients, especially those with high …
NCCN guidelines insights: genetic/familial high-risk assessment: colorectal, version 2.2019: featured updates to the NCCN guidelines
S Gupta, D Provenzale, X Llor, AL Halverson… - Journal of the National …, 2019 - jnccn.org
Identifying individuals with hereditary syndromes allows for improved cancer surveillance,
risk reduction, and optimized management. Establishing criteria for assessment allows for …
risk reduction, and optimized management. Establishing criteria for assessment allows for …
Milestones of Lynch syndrome: 1895–2015
HT Lynch, CL Snyder, TG Shaw, CD Heinen… - Nature Reviews …, 2015 - nature.com
Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …
condition, is characterized by the predisposition to a spectrum of cancers, primarily …
[图书][B] Applications of prediction models
EW Steyerberg, EW Steyerberg - 2009 - Springer
Applications of prediction models | SpringerLink Skip to main content Advertisement
SpringerLink Account Menu Find a journal Publish with us Track your research Search Cart …
SpringerLink Account Menu Find a journal Publish with us Track your research Search Cart …
Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome
V Bonadona, B Bonaïti, S Olschwang, S Grandjouan… - Jama, 2011 - jamanetwork.com
Context Providing accurate estimates of cancer risks is a major challenge in the clinical
management of Lynch syndrome. Objective To estimate the age-specific cumulative risks of …
management of Lynch syndrome. Objective To estimate the age-specific cumulative risks of …
Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002)
SR Cairns, JH Scholefield, RJ Steele, MG Dunlop… - Gut, 2010 - gut.bmj.com
The British Society of Gastroenterology (BSG) and the Association of Coloproctology for
Great Britain and Ireland (ACPGBI) commissioned this update of the 2002 guidance. The …
Great Britain and Ireland (ACPGBI) commissioned this update of the 2002 guidance. The …
The serrated pathway to colorectal carcinoma: current concepts and challenges
Approximately 30% of colorectal carcinomas develop via a serrated neoplasia pathway,
named for the pattern of crypts in the precursor polyps. Molecular abnormalities consistently …
named for the pattern of crypts in the precursor polyps. Molecular abnormalities consistently …
Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability
Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a
common autosomal dominant syndrome characterized by early age at onset, neoplastic …
common autosomal dominant syndrome characterized by early age at onset, neoplastic …