Ligand-docking-based methods are starting to play a critical role in lead discovery and
optimization, thus resulting in new 'drug-candidates'. They offer the possibility to go beyond …

Hybrid molecules, furnished by combining two or more pharmacophores is an emerging
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …

Thrombosis, which seriously endangers human health and life, is the leading cause of
morbidity and mortality globally. Antithrombotic drugs can interfere with the occurrence and …

Thrombosis is the leading cause of illness and mortality worldwide, posing a serious risk to
human health and life. Because antithrombotic drugs can prevent the beginning and …

Coagulation factor XII (FXII), a S1A serine protease, was discovered more than fifty years
ago. However, its in vivo functions and its three-dimensional structure started to be disclosed …

A new synthetic approach employing two types of protecting groups,
tertiarybutyldimethylsilyl (TBDMS) and tertiarybutyloxycarbonyl (Boc) was developed to …

Coumarins represent well-established structures to introduce fluorescence into tool
compounds for biochemical investigations. They are valued for their small size, chemical …

Inhibitors of the coagulation factor XIIa (FXIIa) are attractive to detail the roles of this
protease in hemostasis and thrombosis, to suppress artifact due to contact pathway …

A number of new 4-aryloxymethylcoumarins 3 and 5 have been obtained from the reaction
of various 4-bromomethylcoumarins with 2-nitro-p-cresol 2 and 2, 6-dibromo-p-cresol 4 …

The inhibition of kallikreins 5 and 7, and possibly kallikrein 14 and matriptase,(that initiates
the kallikrein proteolytic cascade) constitutes an innovative way to treat some skin diseases …