Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …

Diabetic nephropathy (DN) is one of the most common complications in diabetes mellitus
and the leading cause of end-stage renal disease. TGF-β is a pleiotropic cytokine and has …

Significance: Intrarenal oxidative stress plays a critical role in the initiation and progression
of diabetic kidney disease (DKD). Enhanced oxidative stress results from overproduction of …

Diabetes-associated morbidity and mortality is predominantly due to complications of the
disease that may cause debilitating conditions, such as heart and renal failure, hepatic …

Transforming growth factor-β1 (TGF-β1) is established to be involved in the pathogenesis of
diabetic nephropathy. The diabetic milieu enhances oxidative stress and induces the …

Proteinuria is the hallmark of diabetic kidney disease (DKD) and is an independent risk
factor for both renal disease progression, and cardiovascular disease. Although the …

Chronic progressive kidney diseases typically are characterized by active renal fibrosis and
inflammation. Transforming growth factor-β1 (TGF-β1) is a key mediator in the development …

В книге представлены современные данные об эпидемиологии, патогенезе,
профилактике и лечении различных вариантов поражения почек при сахарном …

Diabetic nephropathy (DN) is a major diabetic complication that is mediated by transforming
growth factor (TGF)-β1 via Smad-dependent and-independent signalling pathways., Under …

Despite improvements in glycaemic and blood pressure control, and the efficacy of renin–
angiotensin system (RAS) blockade for proteinuria reduction, diabetic nephropathy is the …