Amylin: pharmacology, physiology, and clinical potential
Amylin is a pancreatic β-cell hormone that produces effects in several different organ
systems. Here, we review the literature in rodents and in humans on amylin research since …
systems. Here, we review the literature in rodents and in humans on amylin research since …
GPCR modulation by RAMPs
Our conceptual understanding of the molecular architecture of G-protein coupled receptors
(GPCRs) has transformed over the last decade. Once considered as largely independent …
(GPCRs) has transformed over the last decade. Once considered as largely independent …
Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier
Background The presence of calcitonin gene-related peptide and its receptors in multiple
brain areas and peripheral tissues previously implicated in migraine initiation and its many …
brain areas and peripheral tissues previously implicated in migraine initiation and its many …
Targeting VIP and PACAP receptor signaling: new insights into designing drugs for the PACAP subfamily of receptors
Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and Vasoactive Intestinal Peptide
(VIP) are neuropeptides involved in a diverse array of physiological and pathological …
(VIP) are neuropeptides involved in a diverse array of physiological and pathological …
[HTML][HTML] Amylin brain circuitry
Amylin is a peptide hormone that is mainly known to be produced by pancreatic β-cells in
response to a meal but amylin is also produced by brain cells in discrete brain areas albeit …
response to a meal but amylin is also produced by brain cells in discrete brain areas albeit …
Molecular studies of CGRP and the CGRP family of peptides in the central nervous system
Background Calcitonin gene-related peptide is an important target for migraine and other
painful neurovascular conditions. Understanding the normal biological functions of …
painful neurovascular conditions. Understanding the normal biological functions of …
CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors?
The neuropeptide calcitonin gene‐related peptide (CGRP) is reported to play an important
role in migraine. It is expressed throughout the trigeminovascular system. Antagonists …
role in migraine. It is expressed throughout the trigeminovascular system. Antagonists …
Pathophysiologic and therapeutic implications of adrenomedullin in cardiovascular disorders
T Ishimitsu, H Ono, J Minami, H Matsuoka - Pharmacology & therapeutics, 2006 - Elsevier
Adrenomedullin (AM) is a vasodilator peptide that originally isolated from
pheochromocytoma tissue. However, the mRNA is expressed in the normal adrenal gland …
pheochromocytoma tissue. However, the mRNA is expressed in the normal adrenal gland …
Immunohistochemical mapping of calcitonin receptors in the adult rat brain
C Becskei, T Riediger, D Zünd, P Wookey, TA Lutz - Brain research, 2004 - Elsevier
Calcitonin receptors (CTR) have previously been identified in specific regions of the rat
central nervous system using in situ hybridization or autoradiography with iodinated ligands …
central nervous system using in situ hybridization or autoradiography with iodinated ligands …
Expression of adrenomedullin2/intermedin in human brain, heart, and kidney
R Morimoto, F Satoh, O Murakami, K Totsune, T Suzuki… - Peptides, 2007 - Elsevier
Adrenomedullin2/intermedin (AM2/IMD) is a novel member of the calcitonin/calcitonin gene-
related peptide (CGRP) family. In the present study, we developed a specific …
related peptide (CGRP) family. In the present study, we developed a specific …