Oxidative stress, which results in the damage of diverse biological molecules, is a ubiquitous
cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …

Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional
overdose of acetaminophen (APAP) has affected patients for decades, and involves the …

N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …

The crucial roles of oxidative stress and inflammation in the development of hepatic
diseases have been unraveled and emphasized for decades. From steatosis to fibrosis …

Diethylnitrosamine (DEN) is a well‐known hepatocarcinogen, and its oral administration
causes severe liver damage including cancer. DEN induces the pathogenesis of the liver …

Oxidative stress is induced once the balance of generation and neutralization of reactive
oxygen species (ROS) is broken in the cell, and it plays crucial roles in a variety of natural …

N-acetylcysteine (NAC), a plant antioxidant naturally found in onion, is a precursor to
glutathione. It has been used as a drug since the 1960s and is listed on the World Health …

Background & Aims The risk of hepatocellular carcinoma (HCC) during antiviral therapy in
patients with chronic hepatitis B (CHB) is inadequately predicted by the scores built from …

Acrylamide (ACR) is a classic neurotoxin in animals and humans. However, the mechanism
underlying ACR neurotoxicity remains controversial, and effective prevention and treatment …

Mitochondrial DNA depletion syndrome (MDS) is a group of severe inherited disorders
caused by mutations in genes, such as deoxyribonucleoside kinase (DGUOK). A great …