Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Gram-negative bacteria are protected by a multicompartmental molecular architecture
known as the cell envelope that contains two membranes and a thin cell wall. As the cell …

Accurately capturing domain-domain interactions is key to understanding protein function
and designing structure-based drugs. Although AlphaFold2 has made a breakthrough on …

Microcins are small antibacterial proteins that mediate interbacterial competition. Their
narrow-spectrum activity provides opportunities to discover microbiome-sparing treatments …

Antimicrobial resistance (AMR) remains a major threat to global health. To date, tractable
approaches that decipher how AMR emerges within a bacterial population remain limited …

The selective translocation of molecules through membrane pores is an integral process in
cells. We present a bacterial sugar transporter, CymA of unusual structural conformation due …

Outer membrane vesicles (OMVs) are continuously produced by Gram-negative bacteria
and are increasingly recognized as ubiquitous mediators of bacterial physiology. In …

Indiscriminate use of antibiotics to treat bacterial infections has brought unmanageable
antibiotic-resistant strains into existence. Vibrio spp. represents one such gram-negative …

β barrels are ubiquitous proteins in the outer membranes of mitochondria, chloroplasts, and
Gram-negative bacteria. These transmembrane proteins (TMPs) execute a wide variety of …

Background Membrane proteins constitute a major group of proteins and are of great
significance as pharmaceutical targets, but underrepresented in the Protein Data Bank …