The main features that are commonly attributed to mitochondria consist of the regulation of
cell proliferation, ATP generation, cell death and metabolism. However, recent scientific …

The endoplasmic reticulum (ER) has recently emerged as a promising target for anticancer
agents. Cytotoxic compounds that target the ER often exhibit selectivity for cancer cells over …

Mitochondria are dynamic organelles that have essential metabolic activity and are
regarded as signalling hubs with biosynthetic, bioenergetics and signalling functions that …

The endoplasmic reticulum (ER) and mitochondria are tightly associated with very dynamic
platforms termed mitochondria-associated membranes (MAMs). MAMs provide an excellent …

Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …

In addition to their role in providing cellular energy, mitochondria fulfill a key function in
cellular calcium management. The present review provides an integrative view of cellular …

Mitochondria and endoplasmic reticulum (ER) are fundamental in the control of cell
physiology regulating several signal transduction pathways. They continuously …

The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-
containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and …

Cardiovascular disease is the most common cause of death worldwide and in particular,
ischemic heart disease holds the most considerable position. Even if it has been deeply …

Abstract CDGSH Iron Sulfur Domain 2 (CISD2) is the causative gene for the disease
Wolfram syndrome 2 (WFS2; MIM 604928), which is an autosomal recessive disorder …