Multiscale recordings reveal the dynamic spatial structure of human seizures

CA Schevon, S Tobochnik, T Eissa, E Merricks… - Neurobiology of …, 2019 - Elsevier
The cellular activity underlying human focal seizures, and its relationship to key signatures
in the EEG recordings used for therapeutic purposes, has not been well characterized …

Role of paroxysmal depolarization in focal seizure activity

AK Tryba, EM Merricks, S Lee… - Journal of …, 2019 - journals.physiology.org
We analyze the role of inhibition in sustaining focal epileptic seizure activity. We review
ongoing seizure activity at the mesoscopic scale that can be observed with microelectrode …

Multiple sources of fast traveling waves during human seizures: Resolving a controversy

ED Schlafly, FA Marshall, EM Merricks… - Journal of …, 2022 - Soc Neuroscience
During human seizures, organized waves of voltage activity rapidly sweep across the cortex.
Two contradictory theories describe the source of these fast traveling waves: either a slowly …

Spatiotemporal spike-centered averaging reveals symmetry of temporal and spatial components of the spike-LFP relationship during human focal seizures

S Lee, SS Deshpande, EM Merricks, E Schlafly… - Communications …, 2023 - nature.com
The electrographic manifestation of neural activity can reflect the relationship between the
faster action potentials of individual neurons and the slower fluctuations of the local field …

Divisive gain modulation enables flexible and rapid entrainment in a neocortical microcircuit model

CA Papasavvas, AJ Trevelyan… - Journal of …, 2020 - journals.physiology.org
Neocortical circuits exhibit a rich dynamic repertoire, and their ability to achieve entrainment
(adjustment of their frequency to match the input frequency) is thought to support many …

Novel visualization of the spatiotemporal relationship between ictal spiking and LFP supports the involvement of mid-range excitatory circuits during human focal …

S Lee, SS Deshpande, EM Merricks, E Schlafly… - medRxiv, 2022 - medrxiv.org
The relationship between action potentials and the associated local field potential (LFP) in
neural recordings is typically studied only in the temporal domain using the spike-triggered …

Multiscale Features and Mechanisms of Cortical Epileptiform Activity

S Lee - 2022 - search.proquest.com
Epilepsy is a neurological disorder characterized by recurrent, unprovoked seizures that
produce a distinct signature of hypersynchronous neural activity in electroencephalographic …

Spatiotemporal patterns in microelectrode arrays during human seizures

E Schlafly - 2023 - open.bu.edu
Epilepsy is a disease affecting millions of people worldwide. Despite over 50 years of
research, the mechanisms that generate and sustain ictal discharges, a key neural hallmark …

Spatiotemporal Correlations of Mesoscale Neocortical Activities in Patients with Focal Epilepsy

S Lee, SS Deshpande, EM Merricks, MJAM van Putten… - medRxiv, 2021 - medrxiv.org
Brain function is reflected in both the action potentials of individual neurons and interactions
through eg synaptic currents reflected in widespread, slow fluctuations of the local field …

[HTML][HTML] 50 Years of Modeling Neural Activity: Celebrating Jack Cowan's Career: Divisive gain modulation enables flexible and rapid entrainment in a neocortical …

CA Papasavvas, AJ Trevelyan, M Kaiser… - Journal of …, 2020 - ncbi.nlm.nih.gov
Neocortical circuits exhibit a rich dynamic repertoire, and their ability to achieve entrainment
(adjustment of their frequency to match the input frequency) is thought to support many …