Multiscale recordings reveal the dynamic spatial structure of human seizures
The cellular activity underlying human focal seizures, and its relationship to key signatures
in the EEG recordings used for therapeutic purposes, has not been well characterized …
in the EEG recordings used for therapeutic purposes, has not been well characterized …
Role of paroxysmal depolarization in focal seizure activity
AK Tryba, EM Merricks, S Lee… - Journal of …, 2019 - journals.physiology.org
We analyze the role of inhibition in sustaining focal epileptic seizure activity. We review
ongoing seizure activity at the mesoscopic scale that can be observed with microelectrode …
ongoing seizure activity at the mesoscopic scale that can be observed with microelectrode …
Multiple sources of fast traveling waves during human seizures: Resolving a controversy
ED Schlafly, FA Marshall, EM Merricks… - Journal of …, 2022 - Soc Neuroscience
During human seizures, organized waves of voltage activity rapidly sweep across the cortex.
Two contradictory theories describe the source of these fast traveling waves: either a slowly …
Two contradictory theories describe the source of these fast traveling waves: either a slowly …
Spatiotemporal spike-centered averaging reveals symmetry of temporal and spatial components of the spike-LFP relationship during human focal seizures
S Lee, SS Deshpande, EM Merricks, E Schlafly… - Communications …, 2023 - nature.com
The electrographic manifestation of neural activity can reflect the relationship between the
faster action potentials of individual neurons and the slower fluctuations of the local field …
faster action potentials of individual neurons and the slower fluctuations of the local field …
Divisive gain modulation enables flexible and rapid entrainment in a neocortical microcircuit model
CA Papasavvas, AJ Trevelyan… - Journal of …, 2020 - journals.physiology.org
Neocortical circuits exhibit a rich dynamic repertoire, and their ability to achieve entrainment
(adjustment of their frequency to match the input frequency) is thought to support many …
(adjustment of their frequency to match the input frequency) is thought to support many …
Novel visualization of the spatiotemporal relationship between ictal spiking and LFP supports the involvement of mid-range excitatory circuits during human focal …
S Lee, SS Deshpande, EM Merricks, E Schlafly… - medRxiv, 2022 - medrxiv.org
The relationship between action potentials and the associated local field potential (LFP) in
neural recordings is typically studied only in the temporal domain using the spike-triggered …
neural recordings is typically studied only in the temporal domain using the spike-triggered …
Multiscale Features and Mechanisms of Cortical Epileptiform Activity
S Lee - 2022 - search.proquest.com
Epilepsy is a neurological disorder characterized by recurrent, unprovoked seizures that
produce a distinct signature of hypersynchronous neural activity in electroencephalographic …
produce a distinct signature of hypersynchronous neural activity in electroencephalographic …
Spatiotemporal patterns in microelectrode arrays during human seizures
E Schlafly - 2023 - open.bu.edu
Epilepsy is a disease affecting millions of people worldwide. Despite over 50 years of
research, the mechanisms that generate and sustain ictal discharges, a key neural hallmark …
research, the mechanisms that generate and sustain ictal discharges, a key neural hallmark …
Spatiotemporal Correlations of Mesoscale Neocortical Activities in Patients with Focal Epilepsy
S Lee, SS Deshpande, EM Merricks, MJAM van Putten… - medRxiv, 2021 - medrxiv.org
Brain function is reflected in both the action potentials of individual neurons and interactions
through eg synaptic currents reflected in widespread, slow fluctuations of the local field …
through eg synaptic currents reflected in widespread, slow fluctuations of the local field …
[HTML][HTML] 50 Years of Modeling Neural Activity: Celebrating Jack Cowan's Career: Divisive gain modulation enables flexible and rapid entrainment in a neocortical …
CA Papasavvas, AJ Trevelyan, M Kaiser… - Journal of …, 2020 - ncbi.nlm.nih.gov
Neocortical circuits exhibit a rich dynamic repertoire, and their ability to achieve entrainment
(adjustment of their frequency to match the input frequency) is thought to support many …
(adjustment of their frequency to match the input frequency) is thought to support many …