The preceding papers in this Series have outlined how underuse and overuse of health-care
services occur within a complex system of health-care production, with a multiplicity of …

Background Low-value clinical practices are common in healthcare, yet the optimal
approach to de-adopting these practices is unknown. The objective of this study was to …

BACKGROUND Cost-effectiveness analysis involves the comparison of the incremental cost-
effectiveness ratio of a new technology, which is more costly than existing alternatives, with …

Few health crises have been as predictable as the unfolding obesity pandemic. Clinical and
public health services remain the front line of efforts to reduce the burden of obesity. While a …

Objective: To develop and apply a novel method for scanning a range of sources to identify
existing health care services (excluding pharmaceuticals) that have questionable benefit …

The discontinuation of interventions that should be stopped, or de‐implementation, has
emerged as a novel line of inquiry within dissemination and implementation science. As this …

Over the past 10 years NICE has identified over 800 clinical interventions for potential
disinvestment. But Sarah Garner and Peter Littlejohns report that although disinvestment will …

Background Systematic reviews provide a transparent and robust summary of existing
research. However, health system managers, national and local policy makers and …

Introduction: European countries need to learn from each other to address unsustainable
increases in pharmaceutical expenditures. Objective: To assess the influence of the many …

Pharmaceutical expenditure has increased rapidly across many Organisation for Economic
Cooperation and Development (OECD) countries over the past three decades. This growth …