Functioning as the exterior interface of the human body with the environment, skin acts as a
physical barrier to prevent the invasion of foreign pathogens while providing a home to the …

The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are
still poorly understood, and current therapies are limited. Poor wound healing after trauma …

Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for
restoring the epidermis after injury through a process termed epithelialization. This review …

Foot infections are the main disabling complication in patients with diabetes mellitus. These
infections can lead to lower-limb amputation, increasing mortality and decreasing the quality …

The incidence of chronic wounds is increased among older adults, and the impact of chronic
wounds on quality of life is particularly profound in this population. It is well established that …

Delayed wound healing can cause significant issues for immobile and ageing individuals as
well as those living with co-morbid conditions such as diabetes, cardiovascular disease, and …

As the prevalence of diabetes is increasing globally, secondary complications associated to
this endocrinal disorder are also ascending. Diabetic foot ulcers are potentially modifying …

The skin, the human body's largest organ, is home to a diverse and complex variety of innate
and adaptive immune functions. Despite this potent immune system present at the …

The extent to which microorganisms impair wound healing is an ongoing controversy in the
management of chronic wounds. Because the high diversity and extreme variability of the …

Chronic wounds are a major complication of diabetes associated with high morbidity and
health care expenditures. To investigate the role of colonizing microbiota in diabetic wound …