[HTML][HTML] Long Non-Coding RNAs and Alzheimer's Disease: Towards Personalized Diagnosis

MI Mosquera-Heredia, OM Vidal, LC Morales… - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD), a neurodegenerative disorder characterized by progressive
cognitive decline, is the most common form of dementia. Currently, there is no single test that …

Alzheimer's disease protein relevance analysis using human and mouse model proteomics data

C Shi, WK Gottschalk, CA Colton… - Frontiers in systems …, 2023 - frontiersin.org
The principles governing genotype-phenotype relationships are still emerging (Jovanovic,
Science, 2015, 347 (6,226), 1,259,038; Buccitelli et al., Nature Reviews Genetics, 2020, 21 …

AutoTransOP: translating omics signatures without orthologue requirements using deep learning

N Meimetis, KM Pullen, DY Zhu, A Nilsson… - NPJ Systems Biology …, 2024 - nature.com
The development of therapeutics and vaccines for human diseases requires a systematic
understanding of human biology. Although animal and in vitro culture models can elucidate …

Cross-Species Modeling Identifies Gene Signatures in Type 2 Diabetes Mouse Models Predictive of Inflammatory and Estrogen Signaling Pathways Associated with …

BK Ball, EA Proctor, DK Brubaker - … 2025: Proceedings of the Pacific …, 2024 - World Scientific
Alzheimer's disease (AD), the predominant form of dementia, is influenced by several risk
factors, including type 2 diabetes (T2D), a metabolic disorder characterized by the …

Involvement of microglia‐expressed MS4A6A in the onset of glioblastoma

W Lv, S Lin, Z Zuo, Z Huang… - European Journal of …, 2024 - Wiley Online Library
Glioblastoma multiforme (GBM) represents the deadliest form of brain tumour, characterized
by its low survival rate and grim prognosis. Cytokines released from glioma‐associated …

Cross species modeling reveals a role for the unfolded protein response in shaping the transcriptional reaction to Mycobacterium tuberculosis infection

KM Pullen, R Finethy, SHB Ko, CJ Reames… - bioRxiv, 2024 - biorxiv.org
Numerous blood mRNA signatures have been developed to diagnose tuberculosis (TB)
disease. The utility of these signatures in diverse populations depends on the inclusion of …

Cross-disease modeling of peripheral blood identifies biomarkers of type 2 diabetes predictive of Alzheimer's disease

BK Ball, JH Park, EA Proctor, DK Brubaker - bioRxiv, 2024 - biorxiv.org
Type 2 diabetes (T2D) is a significant risk factor for Alzheimer's disease (AD). Despite
multiple studies reporting this connection, the mechanism by which T2D exacerbates AD is …

Autoencoder Model for Translating Omics Signatures

N Meimetis, KM Pullen, DY Zhu, A Nilsson, TN Hoang… - bioRxiv, 2023 - biorxiv.org
The development of effective therapeutics and vaccines for human diseases requires a
systematic understanding of human biology. While animal and in vitro culture models have …

ARN no codificantes largos exosomales y su papel en la patogénesis de la Enfermedad de Alzheimer

MI Mosquera Heredia - 2023 - manglar.uninorte.edu.co
Los exosomas son nanovesículas extracelulares de origen endocítico, con forma esférica,
delimitada por una membrana lipídica, y diámetro promedio de 30-150 nm. Se sabe que los …