Adrenoceptors as potential target for add-on immunomodulatory therapy in multiple sclerosis
I Pilipović, Z Stojić-Vukanić, G Leposavić - Pharmacology & Therapeutics, 2023 - Elsevier
This review summarizes recent findings related to the role of the sympathetic nervous
system (SNS) in pathogenesis of multiple sclerosis (MS) and its commonly used …
system (SNS) in pathogenesis of multiple sclerosis (MS) and its commonly used …
Chronic effects of the sympathetic nervous system in inflammatory models
G Pongratz, RH Straub - Neuroimmunomodulation, 2023 - karger.com
The immune system is embedded in a network of regulatory systems to keep homeostasis in
case of an immunologic challenge. Neuroendocrine immunologic research has revealed …
case of an immunologic challenge. Neuroendocrine immunologic research has revealed …
Sustainable release of propranolol hydrochloride laden with biconjugated-ufasomes chitosan hydrogel attenuates cisplatin-induced sciatic nerve damage in in vitro/in …
Peripheral nerve injuries significantly impact patients' quality of life and poor functional
recovery. Chitosan–ufasomes (CTS–UFAs) exhibit biomimetic features, making them a …
recovery. Chitosan–ufasomes (CTS–UFAs) exhibit biomimetic features, making them a …
The Dual Role of the β2-Adrenoreceptor in the Modulation of IL-17 and IFN-γ Production by T Cells in Multiple Sclerosis
M Melnikov, V Rogovskii, A Sviridova… - International Journal of …, 2022 - mdpi.com
Norepinephrine is a neurotransmitter that also has an immunomodulatory effect and is
involved in multiple sclerosis (MS) pathogenesis. This study aimed to clarify the role of the …
involved in multiple sclerosis (MS) pathogenesis. This study aimed to clarify the role of the …
Hormones in experimental autoimmune encephalomyelitis (EAE) animal models
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) in which activated immune cells attack the CNS and cause inflammation and …
system (CNS) in which activated immune cells attack the CNS and cause inflammation and …
β-Adrenoceptor blockade moderates neuroinflammation in male and female EAE rats and abrogates sexual dimorphisms in the major neuroinflammatory pathways by …
I Pilipović, Z Stojić-Vukanić, I Prijić, N Jasnić… - Cellular and Molecular …, 2023 - Springer
Our previous studies showed more severe experimental autoimmune encephalomyelitis
(EAE) in male compared with female adult rats, and moderating effect of propranolol …
(EAE) in male compared with female adult rats, and moderating effect of propranolol …
[HTML][HTML] Propranolol diminished severity of rat EAE by enhancing immunoregulatory/protective properties of spinal cord microglia
I Pilipović, Z Stojić-Vukanić, I Prijić, N Jasnić… - Neurobiology of …, 2020 - Elsevier
Sympathetic dysfunction is suggested to contribute to development of multiple sclerosis and
experimental autoimmune encephalomyelitis (EAE) alike. Considering important role of …
experimental autoimmune encephalomyelitis (EAE) alike. Considering important role of …
Stellate Ganglion Block Improves the Proliferation and Function of Splenic CD4+ T Cells Through Inhibition of Posthemorrhagic Shock Mesenteric Lymph–Mediated …
Y Li, HB Du, LN Jiang, C Wang, M Yin, LM Zhang… - Inflammation, 2021 - Springer
Severe hemorrhagic shock leads to excessive inflammation and immune dysfunction, which
results in high mortality related to mesenteric lymph return. A recent study showed that …
results in high mortality related to mesenteric lymph return. A recent study showed that …
Noradrenaline modulates CD4+ T cell priming in rat experimental autoimmune encephalomyelitis: a role for the α1-adrenoceptor
I Pilipović, I Vujnović, Z Stojić-Vukanić, R Petrović… - Immunologic …, 2019 - Springer
Pharmacological blockade of α 1-adrenoceptor is shown to influence development of
experimental autoimmune encephalomyelitis (EAE), an IL-17-producing CD4+ TCR+ (Th17) …
experimental autoimmune encephalomyelitis (EAE), an IL-17-producing CD4+ TCR+ (Th17) …
Progress and promise of nur77-based therapeutics for central nervous system disorders
L Liu, D Ma, L Zhuo, X Pang, J You… - Current …, 2021 - ingentaconnect.com
Nur77 belongs to the NR4A subgroup of the nuclear receptor superfamily. Unlike other
nuclear receptors, a natural ligand for Nur77 has not been identified yet. However, a few …
nuclear receptors, a natural ligand for Nur77 has not been identified yet. However, a few …