Adrenoceptors as potential target for add-on immunomodulatory therapy in multiple sclerosis

I Pilipović, Z Stojić-Vukanić, G Leposavić - Pharmacology & Therapeutics, 2023 - Elsevier
This review summarizes recent findings related to the role of the sympathetic nervous
system (SNS) in pathogenesis of multiple sclerosis (MS) and its commonly used …

Chronic effects of the sympathetic nervous system in inflammatory models

G Pongratz, RH Straub - Neuroimmunomodulation, 2023 - karger.com
The immune system is embedded in a network of regulatory systems to keep homeostasis in
case of an immunologic challenge. Neuroendocrine immunologic research has revealed …

Sustainable release of propranolol hydrochloride laden with biconjugated-ufasomes chitosan hydrogel attenuates cisplatin-induced sciatic nerve damage in in vitro/in …

YM Ahmed, R Orfali, DS Hamad, ME Rateb, HO Farouk - Pharmaceutics, 2022 - mdpi.com
Peripheral nerve injuries significantly impact patients' quality of life and poor functional
recovery. Chitosan–ufasomes (CTS–UFAs) exhibit biomimetic features, making them a …

The Dual Role of the β2-Adrenoreceptor in the Modulation of IL-17 and IFN-γ Production by T Cells in Multiple Sclerosis

M Melnikov, V Rogovskii, A Sviridova… - International Journal of …, 2022 - mdpi.com
Norepinephrine is a neurotransmitter that also has an immunomodulatory effect and is
involved in multiple sclerosis (MS) pathogenesis. This study aimed to clarify the role of the …

Hormones in experimental autoimmune encephalomyelitis (EAE) animal models

M Ghareghani, A Ghanbari, A Eid, A Shaito… - Translational …, 2021 - degruyter.com
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) in which activated immune cells attack the CNS and cause inflammation and …

β-Adrenoceptor blockade moderates neuroinflammation in male and female EAE rats and abrogates sexual dimorphisms in the major neuroinflammatory pathways by …

I Pilipović, Z Stojić-Vukanić, I Prijić, N Jasnić… - Cellular and Molecular …, 2023 - Springer
Our previous studies showed more severe experimental autoimmune encephalomyelitis
(EAE) in male compared with female adult rats, and moderating effect of propranolol …

[HTML][HTML] Propranolol diminished severity of rat EAE by enhancing immunoregulatory/protective properties of spinal cord microglia

I Pilipović, Z Stojić-Vukanić, I Prijić, N Jasnić… - Neurobiology of …, 2020 - Elsevier
Sympathetic dysfunction is suggested to contribute to development of multiple sclerosis and
experimental autoimmune encephalomyelitis (EAE) alike. Considering important role of …

Stellate Ganglion Block Improves the Proliferation and Function of Splenic CD4+ T Cells Through Inhibition of Posthemorrhagic Shock Mesenteric Lymph–Mediated …

Y Li, HB Du, LN Jiang, C Wang, M Yin, LM Zhang… - Inflammation, 2021 - Springer
Severe hemorrhagic shock leads to excessive inflammation and immune dysfunction, which
results in high mortality related to mesenteric lymph return. A recent study showed that …

Noradrenaline modulates CD4+ T cell priming in rat experimental autoimmune encephalomyelitis: a role for the α1-adrenoceptor

I Pilipović, I Vujnović, Z Stojić-Vukanić, R Petrović… - Immunologic …, 2019 - Springer
Pharmacological blockade of α 1-adrenoceptor is shown to influence development of
experimental autoimmune encephalomyelitis (EAE), an IL-17-producing CD4+ TCR+ (Th17) …

Progress and promise of nur77-based therapeutics for central nervous system disorders

L Liu, D Ma, L Zhuo, X Pang, J You… - Current …, 2021 - ingentaconnect.com
Nur77 belongs to the NR4A subgroup of the nuclear receptor superfamily. Unlike other
nuclear receptors, a natural ligand for Nur77 has not been identified yet. However, a few …