Avian toll-like receptors

R Brownlie, B Allan - Cell and tissue research, 2011 - Springer
Abstract Analysis of the genomes of two distantly related bird species, chicken and zebra
finch (divergence of about 100 million years), indicate that there are ten avian toll-like …

Immunostimulatory properties of Toll-like receptor ligands in chickens

MS Paul, JT Brisbin, MF Abdul-Careem… - Veterinary immunology …, 2013 - Elsevier
Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition receptors that
have been identified in mammals and avian species. Ligands for TLRs are typically …

Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides

R Brownlie, J Zhu, B Allan, GK Mutwiri, LA Babiuk… - Molecular …, 2009 - Elsevier
Similar to mammalian species, chickens show marked immunological responses to CpG
oligodeoxynucleotides (ODNs) both in vivo and in vitro. In mammals, the receptor for ODNs …

Development of innate immunity in chicken embryos and newly hatched chicks: a disease control perspective

TN Alkie, A Yitbarek, DC Hodgins, RR Kulkarni… - Avian …, 2019 - Taylor & Francis
Newly hatched chickens are confronted by a wide array of pathogenic microbes because
their adaptive immune defences have limited capabilities to control these pathogens. In such …

Immunostimulatory activities of CpG-oligodeoxynucleotides in teleosts: toll-like receptors 9 and 21

CY Lai, GY Yu, Y Luo, R Xiang, TH Chuang - Frontiers in immunology, 2019 - frontiersin.org
Toll-like receptors (TLRs) are pattern-recognition receptors that detect a wide variety of
microbial pathogens for the initiation of host defense immunological responses. Thirteen …

Prophylactic treatment with Toll-like receptor ligands enhances host immunity to avian influenza virus in chickens

MS Paul, AI Mallick, LR Read, AI Villanueva, P Parvizi… - Vaccine, 2012 - Elsevier
Avian influenza viruses (AIV) pose a threat towards the health of both poultry and humans.
To interrupt the transmission of the virus, novel prophylactic strategies must be considered …

Avian pattern recognition receptor sensing and signaling

SN Neerukonda, U Katneni - Veterinary sciences, 2020 - mdpi.com
Pattern recognition receptors (PRRs) are a class of immune sensors that play a critical role
in detecting and responding to several conserved patterns of microorganisms. As such, they …

Determining the protective efficacy of Toll-like receptor ligands to minimize H9N2 avian influenza virus transmission in chickens

S Raj, M Alizadeh, B Shoojadoost, D Hodgins, É Nagy… - Viruses, 2023 - mdpi.com
Low-pathogenicity avian influenza viruses (AIV) of the H9N2 subtype can infect and cause
disease in chickens. Little is known about the efficacy of immune-based strategies for …

In vivo administration of ligands for chicken toll-like receptors 4 and 21 induces the expression of immune system genes in the spleen

MS Paul, AI Mallick, K Haq, S Orouji… - Veterinary Immunology …, 2011 - Elsevier
Toll-like receptors (TLRs) are a group of conserved proteins that play an important role in
pathogen recognition in addition to the initiation and regulation of innate and adaptive …

Co-stimulation with TLR3 and TLR21 ligands synergistically up-regulates Th1-cytokine IFN-γ and regulatory cytokine IL-10 expression in chicken monocytes

H He, KJ Genovese, CL Swaggerty… - Developmental & …, 2012 - Elsevier
Toll-like receptors (TLRs) are pattern recognition receptors of the innate immune system for
various conserved pathogen-associated molecular motifs. Chicken TLR3 and TLR21 (avian …