Prion diseases affect a wide range of mammal species and are caused by a misfolded self-
propagating isoform (PrPSc) of the normal prion protein (PrPC). Distinct strains of prions …

The principal pathogenic event in Parkinson's disease is characterized by the
conformational change of α-synuclein, which form pathological aggregates of misfolded …

Prion diseases are sub-acute neurodegenerative diseases that affect humans and some
domestic and free-ranging animals. Infectious prion agents are considered to comprise …

Prions, the agents causing transmissible spongiform encephalopathies, colonize the brain of
hosts after oral, parenteral, intralingual, or even transdermal uptake. However, prions are not …

Prion strains are characterized by strain-specific differences in neuropathology but can also
differ in incubation period, clinical disease, host-range and tissue tropism. The hyper (HY) …

Prion disorders are infectious, neurodegenerative diseases that affect humans and animals.
Susceptibility to some prion diseases such as kuru or the new variant of Creutzfeldt‐Jakob …

Little is known regarding the potential risk posed by aerosolized prions. Chronic wasting
disease (CWD) is transmitted horizontally, almost surely by mucosal exposure, and CWD …

Scrapie of sheep and chronic wasting disease (CWD) of cervids are transmissible prion
diseases. Milk and placenta have been identified as sources of scrapie prions but do not …

Prion diseases are progressive neurodegenerative disorders affecting humans and various
mammals. The prominent neuropathological change in prion-affected brains is …

This study investigated the role of prion infection of the olfactory mucosa in the shedding of
prion infectivity into nasal secretions. Prion infection with the HY strain of the transmissible …