Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

Obesity results from a synergistic relationship between genes and the environment. The
phenotypic expression of genetic factors involved in obesity is variable, allowing to …

It is well-known that obesity is a complex multifactorial and heterogeneous condition with an
important genetic component. Recently, major advances in obesity research emerged …

The melanocortin-4 receptor (MC4R)–embedded in the leptin–melanocortin pathway–is
activated by proopiomelanocortin (POMC)-derived neuropeptides such as α-and β …

The variation in weight within a shared environment is largely attributable to genetic factors.
Whilst many genes/loci confer susceptibility to obesity, little is known about the genetic …

This discussion reflects on concepts of obesity in children and adolescents in the early 21st
century. It includes reflections on its history, definition, epidemiology, diagnostic …

Context: Activation of the melanocortin-4 receptor (MC4R) with the synthetic agonist RM-493
decreases body weight and increases energy expenditure (EE) in nonhuman primates. The …

Abstract Purpose of Review This review aims to present current information on genes
underlying severe obesity, with the main emphasis on the three genes LEP, LEPR and …

G protein-coupled receptors (GPCRs) are membrane proteins that traverse the plasma
membrane seven times (hence, are also called 7TM receptors). The polytopic structure of …

The dysfunction of melanocortin signaling has been associated with obesity, given the
important role in the regulation of energy homeostasis, food intake, satiety and body weight …