Human structural congenital malformations are the leading cause of infant mortality in the
United States. Estimates from the United States Center for Disease Control and Prevention …

Neural tube defects (NTDs), including spina bifida and anencephaly, represent the most
severe and common malformations of the central nervous system affecting 0.7–3 per 1000 …

Spina bifida is the most common congenital defect of the central nervous system which can
portend lifelong disability to those afflicted. While the complete underpinnings of this disease …

Neural tube defects (NTDs) are a classic example of preventable birth defects for which
there is a proven‐effective intervention, folic acid (FA); however, further methods of …

The analysis of whole-genome sequencing studies is challenging due to the large number
of rare variants in noncoding regions and the lack of natural units for testing. We propose a …

Neural tube defects (NTDs) are a broad class of congenital birth defects that result from the
failure of neural tube closure during neurulation. Folic acid supplementation has been …

The neural tube is the first critically important structure that develops in the embryo. It serves
as the primordium of the central nervous system; therefore, the proper formation of the …

Neural tube defects (NTDs) represent a failure of the neural plate to complete the
developmental transition to a neural tube. NTDs are the most common birth anomaly of the …

Structural anomalies of the central nervous system (CNS) are one of the most common fetal
anomalies found during prenatal imaging. However, the genomic architecture of prenatal …

Neural tube defects (NTDs) are among the most common birth defects, with a prevalence of
close to 19 per 10,000 births worldwide. The etiology of NTDs is complex involving the …