Achalasia is a rare disorder of the oesophageal smooth muscle characterized by impaired
relaxation of the lower oesophageal sphincter (LES) and absent or spastic contractions in …

Idiopathic achalasia is an archetype esophageal motor disorder, causing significant
impairment of eating ability and reducing quality of life. The pathophysiological …

Dysphagia is a common symptom that is important to recognise and appropriately manage,
given that causes include life threatening oesophageal neoplasia, oropharyngeal …

There is accumulating evidence suggesting that an autoimmune component is involved in
esophageal achalasia. An increase in immune cells, cytokines, chemokines, and …

Objectives: Achalasia is a primary motility disorder of the esophagus characterized by
aperistalsis and failure of lower esophageal sphincter (LES) relaxation. Treatment of …

Idiopathic achalasia is a relatively infrequent esophageal motor disorder for which major
histocompatibility complex (MHC) genes are well-identified risk factors. However, no …

Methods We performed high-dimensional flow cytometry to identified subsets of peripheral
leukocytes, and further validated in lower esophageal sphincter histologically. RNA …

Idiopathic achalasia (IA) is a severe motility disorder characterized by neuronal
degeneration in the myenteric plexus, but the etiology remains largely unknown. We …

Objectives: Achalasia is a primary esophageal motility disorder resulting from selective loss
of inhibitory neurons in the esophageal myenteric plexus, likely due to an autoimmune …

Achalasia is a rare and complex esophageal disease of unknown etiology characterized by
difficulty in swallowing due to the lack of opening of the lower esophageal sphincter and the …