The administration of reserpine to rodents was one of the first models used to investigate the
pathophysiology and screening for potential treatments of P arkinson's disease (PD). The …

Animal models are widely used to study alterations caused by Parkinson's disease (PD).
However, in general, pharmacological models do not express the progressive nature of the …

Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that presents
antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson's …

Monosialoganglioside (GM1) is a glycosphingolipid that protects against some neurological
conditions, such as seizures and ischemia. Glutaric acidemia type I (GA-I) is an inherited …

Rationale Reserpine, a monoamine-depleting agent, which irreversibly and non-selectively
blocks the vesicular monoamine transporter, has been used as an animal model to study …

It has been shown that exercise is helpful against brain disorders. However, this may not be
true for intense exercise (IE). Because it is easy to misadjust exercise intensity with physical …

Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
degeneration of dopaminergic neurons in the substantia nigra pars compact (SNpc), with …

The purpose of the present study was to investigate whether ɑ-tocopherol exhibited neuro-
protective effects in chronic unpredictable mild stress (CUMS) mice through the regulation of …

A single, 6 mg/kg intraperitoneal injection of reserpine increased floating time during forced
swim testing 24 h after administration in rats in five experiments. Although such behavioral …

Several neurological diseases are related to oxidative stress (OS) and neurotoxicity.
Considering that physical exercise may exert beneficial effects on antioxidant defenses, our …