Amino assets: how amino acids support immunity
Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …
is well defined, but they contribute to a host of other intracellular metabolic pathways …
Methionine metabolism in health and cancer: a nexus of diet and precision medicine
Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …
The U6 snRNA m6A methyltransferase METTL16 regulates SAM synthetase intron retention
Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for
a wide variety of biological processes. We demonstrate that the N 6-adenosine …
a wide variety of biological processes. We demonstrate that the N 6-adenosine …
The life and times of a tRNA
EM Phizicky, AK Hopper - RNA, 2023 - rnajournal.cshlp.org
The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …
and insights in the last several years. We now have unprecedented knowledge of each step …
Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species
AA Parkhitko, P Jouandin, SE Mohr, N Perrimon - Aging cell, 2019 - Wiley Online Library
Methionine restriction (MetR) extends lifespan across different species and exerts beneficial
effects on metabolic health and inflammatory responses. In contrast, certain cancer cells …
effects on metabolic health and inflammatory responses. In contrast, certain cancer cells …
Optimization of codon translation rates via tRNA modifications maintains proteome integrity
DD Nedialkova, SA Leidel - Cell, 2015 - cell.com
Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome
transit along a given mRNA can influence nascent chain folding, but the extent to which …
transit along a given mRNA can influence nascent chain folding, but the extent to which …
Persulfidation proteome reveals the regulation of protein function by hydrogen sulfide in diverse biological processes in Arabidopsis
Hydrogen sulfide-mediated signaling pathways regulate many physiological and
pathophysiological processes in mammalian and plant systems. The molecular mechanism …
pathophysiological processes in mammalian and plant systems. The molecular mechanism …
Unconventional secretion of Magnaporthe oryzae effectors in rice cells is regulated by tRNA modification and codon usage control
Microbial pathogens deploy effector proteins to manipulate host cell innate immunity, often
using poorly understood unconventional secretion routes. Transfer RNA (tRNA) anticodon …
using poorly understood unconventional secretion routes. Transfer RNA (tRNA) anticodon …
[HTML][HTML] Nutrient-sensing mechanisms across evolution
L Chantranupong, RL Wolfson, DM Sabatini - Cell, 2015 - cell.com
For organisms to coordinate their growth and development with nutrient availability, they
must be able to sense nutrient levels in their environment. Here, we review select nutrient …
must be able to sense nutrient levels in their environment. Here, we review select nutrient …
A metabolic function for phospholipid and histone methylation
S-adenosylmethionine (SAM) is the methyl donor for biological methylation modifications
that regulate protein and nucleic acid functions. Here, we show that methylation of a …
that regulate protein and nucleic acid functions. Here, we show that methylation of a …