Endothelial cells (EC) form a unique signal-transducing surface in the vascular system. The
abundance of ion channels in the plasma membrane of these nonexcitable cells has raised …

It is clear from the preceding overview of histamine receptor pharmacology that research into
the pharmacology of histamine receptors is at an exciting stage of development. The rapid …

In fura-2-loaded ECV304 cells ionomycin elicited a saturable biphasic change in
intracellular Ca2+ concentration ([Ca2+] i), where the initial phase represented mobilization …

Endothelial cells in vivo form an interface between flowing blood and vascular tissue,
responding to humoral and physical stimuli to secrete relaxing and contracting factors that …

▪ Abstract The functional impact of ion channels in vascular endothelial cells (ECs) is still a
matter of controversy. This review describes different types of ion channels in ECs and their …

Background: Hyperreactivity of the nasal mucosa is a characteristic of nasal allergy. During
pregnancy, aggravation of nasal allergic symptoms is occasionally observed in subjects with …

1. Isolated native endothelial cells, obtained by treatment of rabbit aortic endothelium with
papain and dithiothreitol, were voltage clamped, and single channel (unitary) and …

Background Histamine is the most important chemical mediator in the pathogenesis of nasal
allergy. Diesel exhaust particulates (DEPs) are common air pollutants from diesel engine …

1. We have used the whole‐cell patch‐clamp technique to characterize the ionic
conductances that determine the resting membrane potential in cultured endothelial cells …

Postoperative cognitive dysfunction (POCD) has been hypothesized to be mediated by
surgery-induced neuroinflammation, which is also a key element in the pathobiology of …