Redox activation of metal-based prodrugs as a strategy for drug delivery
N Graf, SJ Lippard - Advanced drug delivery reviews, 2012 - Elsevier
This review provides an overview of metal-based anticancer drugs and drug candidates. In
particular, we focus on metal complexes that can be activated in the reducing environment of …
particular, we focus on metal complexes that can be activated in the reducing environment of …
The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes.
H Beraldo, D Gambino - Mini reviews in medicinal chemistry, 2004 - europepmc.org
The more significant bioactivities of a variety of semicarbazones (anti-protozoa,
anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and …
anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and …
Inorganic nanoparticles in cancer therapy
S Bhattacharyya, RA Kudgus, R Bhattacharya… - Pharmaceutical …, 2011 - Springer
Nanotechnology is an evolving field with enormous potential for biomedical applications.
The growing interest to use inorganic nanoparticles in medicine is due to the unique size …
The growing interest to use inorganic nanoparticles in medicine is due to the unique size …
Basis for design and development of platinum (IV) anticancer complexes
MD Hall, HR Mellor, R Callaghan… - Journal of medicinal …, 2007 - ACS Publications
Platinum (II) complexes are widely employed in cancer chemotherapy, but their efficacy
against the majority of malignancies is limited. The reasons for this failure are a combination …
against the majority of malignancies is limited. The reasons for this failure are a combination …
Impact of tumor hypoxia and anemia on radiation therapy outcomes
LB Harrison, M Chadha, RJ Hill, K Hu… - The oncologist, 2002 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader will be able to: Discuss
the prognostic significance of intratumoral hypoxia and low hemoglobin levels in patients …
the prognostic significance of intratumoral hypoxia and low hemoglobin levels in patients …
Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine
The fields of phototherapy and of inorganic chemotherapy both have long histories.
Inorganic photoactivated chemotherapy (PACT) offers both temporal and spatial control over …
Inorganic photoactivated chemotherapy (PACT) offers both temporal and spatial control over …
Copper complexes of bis (thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals
BM Paterson, PS Donnelly - Chemical Society Reviews, 2011 - pubs.rsc.org
The molecules known as bis (thiosemicarbazones) derived from 1, 2-diones can act as
tetradentate ligands for Cu (II), forming stable, neutral complexes. As a family, these …
tetradentate ligands for Cu (II), forming stable, neutral complexes. As a family, these …
Developing new metal-based therapeutics: challenges and opportunities
TW Hambley - Dalton Transactions, 2007 - pubs.rsc.org
Unexpected side effects and problems experienced in clinical trials have created a difficult
environment for those developing new pharmaceuticals and, as a consequence, the number …
environment for those developing new pharmaceuticals and, as a consequence, the number …
Copper bis (thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships
Copper (II) bis (thiosemicarbazone) complexes labelled with Cu-60/62/64 are useful
radiopharmaceuticals for imaging blood flow and hypoxic tissues in vivo. The aim of this …
radiopharmaceuticals for imaging blood flow and hypoxic tissues in vivo. The aim of this …
[图书][B] Terpyridine-based materials: for catalytic, optoelectronic and life science applications
In recent years, the utilization of terpyridines both in macromolecular structure assembly and
device chemistry has exploded, enabling, for example, supramolecular polymer …
device chemistry has exploded, enabling, for example, supramolecular polymer …