Redox activation of metal-based prodrugs as a strategy for drug delivery

N Graf, SJ Lippard - Advanced drug delivery reviews, 2012 - Elsevier
This review provides an overview of metal-based anticancer drugs and drug candidates. In
particular, we focus on metal complexes that can be activated in the reducing environment of …

The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes.

H Beraldo, D Gambino - Mini reviews in medicinal chemistry, 2004 - europepmc.org
The more significant bioactivities of a variety of semicarbazones (anti-protozoa,
anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and …

Inorganic nanoparticles in cancer therapy

S Bhattacharyya, RA Kudgus, R Bhattacharya… - Pharmaceutical …, 2011 - Springer
Nanotechnology is an evolving field with enormous potential for biomedical applications.
The growing interest to use inorganic nanoparticles in medicine is due to the unique size …

Basis for design and development of platinum (IV) anticancer complexes

MD Hall, HR Mellor, R Callaghan… - Journal of medicinal …, 2007 - ACS Publications
Platinum (II) complexes are widely employed in cancer chemotherapy, but their efficacy
against the majority of malignancies is limited. The reasons for this failure are a combination …

Impact of tumor hypoxia and anemia on radiation therapy outcomes

LB Harrison, M Chadha, RJ Hill, K Hu… - The oncologist, 2002 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader will be able to: Discuss
the prognostic significance of intratumoral hypoxia and low hemoglobin levels in patients …

Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine

NJ Farrer, L Salassa, PJ Sadler - Dalton Transactions, 2009 - pubs.rsc.org
The fields of phototherapy and of inorganic chemotherapy both have long histories.
Inorganic photoactivated chemotherapy (PACT) offers both temporal and spatial control over …

Copper complexes of bis (thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals

BM Paterson, PS Donnelly - Chemical Society Reviews, 2011 - pubs.rsc.org
The molecules known as bis (thiosemicarbazones) derived from 1, 2-diones can act as
tetradentate ligands for Cu (II), forming stable, neutral complexes. As a family, these …

Developing new metal-based therapeutics: challenges and opportunities

TW Hambley - Dalton Transactions, 2007 - pubs.rsc.org
Unexpected side effects and problems experienced in clinical trials have created a difficult
environment for those developing new pharmaceuticals and, as a consequence, the number …

Copper bis (thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships

JL Dearling, JS Lewis, GE Mullen, MJ Welch… - JBIC Journal of …, 2002 - Springer
Copper (II) bis (thiosemicarbazone) complexes labelled with Cu-60/62/64 are useful
radiopharmaceuticals for imaging blood flow and hypoxic tissues in vivo. The aim of this …

[图书][B] Terpyridine-based materials: for catalytic, optoelectronic and life science applications

US Schubert, A Winter, GR Newkome - 2012 - books.google.com
In recent years, the utilization of terpyridines both in macromolecular structure assembly and
device chemistry has exploded, enabling, for example, supramolecular polymer …