Multiorgan-on-a-chip: a systemic approach to model and decipher inter-organ communication

N Picollet-D'hahan, A Zuchowska, I Lemeunier… - Trends in …, 2021 - cell.com
Multiorgan-on-a-chip (multi-OoC) platforms have great potential to redefine the way in which
human health research is conducted. After briefly reviewing the need for comprehensive …

Beyond polydimethylsiloxane: alternative materials for fabrication of organ-on-a-chip devices and microphysiological systems

SB Campbell, Q Wu, J Yazbeck, C Liu… - ACS biomaterials …, 2020 - ACS Publications
Polydimethylsiloxane (PDMS) is the predominant material used for organ-on-a-chip devices
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …

Microfluidics for drug development: from synthesis to evaluation

Y Liu, L Sun, H Zhang, L Shang, Y Zhao - Chemical reviews, 2021 - ACS Publications
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

Microfluidic integration of regeneratable electrochemical affinity-based biosensors for continual monitoring of organ-on-a-chip devices

J Aleman, T Kilic, LS Mille, SR Shin, YS Zhang - Nature Protocols, 2021 - nature.com
Organs-on-chips have emerged as viable platforms for drug screening and personalized
medicine. While a wide variety of human organ-on-a-chip models have been developed …

[HTML][HTML] Recent advances in defined hydrogels in organoid research

Z Gan, X Qin, H Liu, J Liu, J Qin - Bioactive Materials, 2023 - Elsevier
Organoids are in vitro model systems that mimic the complexity of organs with multicellular
structures and functions, which provide great potential for biomedical and tissue …

Microfluidic organoids-on-a-chip: The future of human models

G Saorin, I Caligiuri, F Rizzolio - Seminars in cell & developmental biology, 2023 - Elsevier
Microfluidics opened the possibility to model the physiological environment by controlling
fluids flows, and therefore nutrients supply. It allows to integrate external stimuli such as …

3D printing techniques and their applications to organ-on-a-chip platforms: a systematic review

V Carvalho, I Gonçalves, T Lage, RO Rodrigues… - Sensors, 2021 - mdpi.com
Three-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging
and effective technology that allows the replication of the function of tissues and organs …

[HTML][HTML] Organ-on-a-chip meets artificial intelligence in drug evaluation

S Deng, C Li, J Cao, Z Cui, J Du, Z Fu, H Yang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …

Electrochemical sensing directions for next-generation healthcare: trends, challenges, and frontiers

JF Hernández-Rodríguez, D Rojas… - Analytical …, 2020 - ACS Publications
Unfortunately, last year we have witnessed one of the worst global health crises in recent
history. SARS-COV-2 pandemic outbreak has revealed that global healthcare systems were …

Hydrogels as artificial matrices for cell seeding in microfluidic devices

F Akther, P Little, Z Li, NT Nguyen, HT Ta - RSC advances, 2020 - pubs.rsc.org
Hydrogel-based artificial scaffolds play a vital role in shifting in vitro models from two-
dimensional (2D) cell culture to three-dimensional (3D) cell culture. Microfluidic 3D cell …