Digital microfluidics for biological analysis and applications

X Xu, L Cai, S Liang, Q Zhang, S Lin, M Li, Q Yang… - Lab on a Chip, 2023 - pubs.rsc.org
Digital microfluidics (DMF) is an emerging liquid-handling technology based on arrays of
microelectrodes for the precise manipulation of discrete droplets. DMF offers the benefits of …

Machine learning enables design automation of microfluidic flow-focusing droplet generation

A Lashkaripour, C Rodriguez, N Mehdipour… - Nature …, 2021 - nature.com
Droplet-based microfluidic devices hold immense potential in becoming inexpensive
alternatives to existing screening platforms across life science applications, such as enzyme …

[HTML][HTML] Digital microfluidics as an emerging tool for bacterial protocols

CR Nemr, AA Sklavounos, AR Wheeler, SO Kelley - SLAS technology, 2023 - Elsevier
Bacteria are widely studied in various research areas, including synthetic biology,
sequencing and diagnostic testing. Protocols involving bacteria are often multistep …

Automated miniaturized digital microfluidic antimicrobial susceptibility test using a chip-integrated optical oxygen sensor

W Qiu, S Nagl - ACS sensors, 2021 - ACS Publications
We present the first digital microfluidic (DMF) antimicrobial susceptibility test (AST) using an
optical oxygen sensor film for in-situ and real-time continuous measurement of extracellular …

An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting

F Ahmadi, K Samlali, PQN Vo, SCC Shih - Lab on a Chip, 2019 - pubs.rsc.org
Droplet microfluidics is a technique that has the ability to compartmentalize reactions in sub
nano-(or pico-) liter volumes that can potentially enable millions of distinct biological assays …

Integrating machine learning and digital microfluidics for screening experimental conditions

F Ahmadi, M Simchi, JM Perry, S Frenette, H Benali… - Lab on a Chip, 2023 - pubs.rsc.org
Digital microfluidics (DMF) has the signatures of an ideal liquid handling platform–as shown
through almost two decades of automated biological and chemical assays. However, in the …

Determination of blood lithium-ion concentration using digital microfluidic whole-blood separation and preloaded paper sensors

T Komatsu, M Tokeshi, SK Fan - Biosensors and Bioelectronics, 2022 - Elsevier
Existing microfluidic technologies for blood tests have several limitations, including
difficulties in integrating the sample preparation steps, such as blood dilution, and precise …

An automated microfluidic gene-editing platform for deciphering cancer genes

H Sinha, ABV Quach, PQN Vo, SCC Shih - Lab on a Chip, 2018 - pubs.rsc.org
Gene-editing techniques such as RNA-guided endonuclease systems are becoming
increasingly popular for phenotypic screening. Such screens are normally conducted in …

Rapid production and recovery of cell spheroids by automated droplet microfluidics

K Langer, HN Joensson - SLAS TECHNOLOGY: Translating …, 2020 - journals.sagepub.com
The future of the life sciences is linked to automation and microfluidics. As robots start
working side by side with scientists, robotic automation of microfluidics in general, and …

Development and Evaluation of a Low-Cost Triglyceride Quantification Enzymatic Biosensor Using an Arduino-Based Microfluidic System

JE Pliego-Sandoval, A Díaz-Barbosa, LA Reyes-Nava… - Biosensors, 2023 - mdpi.com
Overweight and obesity promote diabetes and heart disease onset. Triglycerides are key
biomarkers for cardiovascular disease, strokes, and other health issues. Scientists have …