Experience with dose response and mechanisms of toxicity has shown that multiple
mechanisms may exist for a single agent along the continuum of the full dose–response …

Alkyl epoxides are important intermediates in the chemical industry. They are also formed in
vivo during the detoxification of alkenes. Alkyl epoxides have shown genotoxicity in many …

Abstract At the International Workshop on Genotoxicity Test Procedures (IWGTP) held in
Washington, DC (March 25–26, 1999), a working group considered the uses of DNA adduct …

1, 3-Butadiene (BD) is a high-volume chemical used in the production of rubber and plastic.
BD is a potent carcinogen in mice and a much weaker carcinogen in rats, and has been …

Butadiene (BD) is an important industrial and environmental chemical classified as a human
carcinogen based on epidemiologic studies in occupationally exposed workers and animal …

Tissue inflammation and chronic infection lead to the overproduction of nitric oxide and
superoxide. These two species rapidly combine to yield peroxynitrite (ONOO−), a powerful …

1, 2, 3, 4-Diepoxybutane (DEB) is a bifunctional alkylating agent that exhibits both cytotoxic
and promutagenic properties. DEB is the ultimate carcinogenic species of the major …

Butadiene (BD) is a high volume industrial chemical which is known as a multi‐site rodent
carcinogen and is classified as a probable human carcinogen. Covalent interactions of the …

1, 2, 3, 4-Diepoxybutane (DEB) is a bifunctional electrophile capable of forming DNA− DNA
and DNA− protein cross-links. DNA alkylation by DEB produces N7-(2 '-hydroxy-3 ', 4 ' …

Smoking is a leading cause of lung cancer, accounting for 81% of lung cancer cases.
Tobacco smoke contains over 5000 compounds, of which more than 70 have been …