The osteosarcoma microenvironment: a complex but targetable ecosystem
Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children,
adolescents, and young adults, and with a second peak of incidence in elderly individuals …
adolescents, and young adults, and with a second peak of incidence in elderly individuals …
Targeting molecular mechanisms underlying treatment efficacy and resistance in osteosarcoma: a review of current and future strategies
I Lilienthal, N Herold - International journal of molecular sciences, 2020 - mdpi.com
Osteosarcoma is the most common primary malignant bone tumour in children and
adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure …
adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure …
Biomimetic metal–organic framework nanoparticles for cooperative combination of antiangiogenesis and photodynamic therapy for enhanced efficacy
Photodynamic therapy (PDT) is a promising anticancer treatment and is clinically approved
for different types of tumors. However, current PDT suffers several obstacles, including its …
for different types of tumors. However, current PDT suffers several obstacles, including its …
Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study
F Duffaud, O Mir, P Boudou-Rouquette… - The Lancet …, 2019 - thelancet.com
Background Regorafenib has proven activity in patients with pretreated gastrointestinal
stromal tumours and colorectal and hepatocellular carcinoma. We designed REGOBONE to …
stromal tumours and colorectal and hepatocellular carcinoma. We designed REGOBONE to …
Overcoming the limits of hypoxia in photodynamic therapy: a carbonic anhydrase IX-targeted approach
A major challenge in photodynamic cancer therapy (PDT) is avoiding PDT-induced hypoxia,
which can lead to cancer recurrence and progression through activation of various …
which can lead to cancer recurrence and progression through activation of various …
Lenvatinib with etoposide plus ifosfamide in patients with refractory or relapsed osteosarcoma (ITCC-050): a multicentre, open-label, multicohort, phase 1/2 study
N Gaspar, R Venkatramani, S Hecker-Nolting… - The Lancet …, 2021 - thelancet.com
Background Tyrosine kinase inhibitors have shown activity in osteosarcoma and might
enhance the efficacy of chemotherapy. We aimed to determine the recommended phase 2 …
enhance the efficacy of chemotherapy. We aimed to determine the recommended phase 2 …
Molecular mechanisms underpinning sarcomas and implications for current and future therapy
Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical
management is highly challenging due to their heterogeneity and insensitivity to current …
management is highly challenging due to their heterogeneity and insensitivity to current …
Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
HF Dvorak - Journal of clinical oncology, 2002 - ascopubs.org
Vascular endothelial growth factor A (VEGF-A), the founding member of the vascular
permeability factor (VPF)/VEGF family of proteins, is an important angiogenic cytokine with …
permeability factor (VPF)/VEGF family of proteins, is an important angiogenic cytokine with …
Angiogenesis inhibitors: current strategies and future prospects
Angiogenesis has become an attractive target for drug therapy because of its key role in
tumor growth. An extensive array of compounds is currently in preclinical development, with …
tumor growth. An extensive array of compounds is currently in preclinical development, with …
[HTML][HTML] A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian Sarcoma Group …
G Grignani, E Palmerini, P Dileo, SD Asaftei… - Annals of …, 2012 - Elsevier
Purpose After standard multimodal therapy, the prognosis of relapsed and unresectable
high-grade osteosarcoma is dismal and unchanged over the last decades. Recently …
high-grade osteosarcoma is dismal and unchanged over the last decades. Recently …