Valproic acid induced liver injury: An insight into molecular toxicological mechanism

D Ezhilarasan, U Mani - Environmental Toxicology and Pharmacology, 2022 - Elsevier
Valproic acid (VPA) is an anti-seizure drug that causes idiosyncratic liver injury. 2-propyl-4-
pentenoic acid (Δ 4 VPA), a metabolite of VPA, has been implicated in VPA-induced …

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

K Sato, F Meng, H Francis, N Wu, L Chen… - Journal of pineal …, 2020 - Wiley Online Library
Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic
nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the …

Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy

FM Kandemir, M Ileriturk, C Gur - Molecular biology reports, 2022 - Springer
Background The present study investigated the effects of rutin (RUT), which has various
biological and pharmacological properties, on liver and kidney damage caused by histone …

Heavy metal pollution and risk assessment by the battery of toxicity tests

MS Khan, M Javed, MT Rehman, M Urooj… - Scientific Reports, 2020 - nature.com
The current study was carried out on dominant fish Oreochromis niloticus and water
collected from the polluted Yamuna River, Agra, India. The heavy metals in water, recorded …

[HTML][HTML] Bioaccumulation of heavy metals and their toxicity assessment in Mystus species

S Tabrez, TA Zughaibi, M Javed - Saudi Journal of Biological Sciences, 2021 - Elsevier
This study was conducted on two native fish species namely Mystus vittatus and Mystus
tengara inhabiting challenging environment of Yamuna River. The heavy metals …

Syringic acid and silymarin concurrent administration inhibits sodium valproate‐induced liver injury in rats

S Gheena, D Ezhilarasan, K Shree Harini… - Environmental …, 2022 - Wiley Online Library
Sodium valproate (SV) is a well‐known anti‐epileptic drug, also used to control convulsions,
bipolar disorders and migraines. SV has been shown to induce liver toxicity in clinical …

The implication of LPS/TLR4 and FXR receptors in hepatoprotective efficacy of indole-3-acetic acid and chenodeoxycholic acid

AS Aljarboa, AM Alhusaini, WS Sarawi, R Mohammed… - Life Sciences, 2023 - Elsevier
Aim Valproic acid (VPA) belongs to the first-generation antiepileptic drugs, yet its prolonged
use can cause life-threatening liver damage. The importance of our study is to investigate …

Protective effects of naringin on valproic acid-induced hepatotoxicity in rats

OF Koroglu, M Gunata, N Vardi, A Yildiz, B Ates… - Tissue and Cell, 2021 - Elsevier
Valproic acid (VPA) is mainly prescribed to treat epilepsy. VPA has been reported to be
associated with many adverse effects, including hepatotoxicity. Naringin (NRG) is a natural …

Labeo rohita, a bioindicator for water quality and associated biomarkers of heavy metal toxicity

M Mahamood, M Javed, SS Alhewairini, F Zahir… - NPJ Clean …, 2021 - nature.com
This study investigated the effect of heavy metals on Labeo rohita inhabiting the Yamuna
River, India. Levels of heavy metals measured in the water were as follows: Fe> Mn> Zn> …

Role of melatonin and quercetin as countermeasures to the mitochondrial dysfunction induced by titanium dioxide nanoparticles

N Nalika, M Waseem, P Kaushik, M Salman… - Life Sciences, 2023 - Elsevier
Aim Due to the growing commercialization of titanium dioxide nanoparticles (TNPs), it is
necessary to use these particles in a manner that is safe, healthy and environmental friendly …