Valproic acid induced liver injury: An insight into molecular toxicological mechanism
D Ezhilarasan, U Mani - Environmental Toxicology and Pharmacology, 2022 - Elsevier
Valproic acid (VPA) is an anti-seizure drug that causes idiosyncratic liver injury. 2-propyl-4-
pentenoic acid (Δ 4 VPA), a metabolite of VPA, has been implicated in VPA-induced …
pentenoic acid (Δ 4 VPA), a metabolite of VPA, has been implicated in VPA-induced …
Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies
Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic
nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the …
nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the …
Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy
Background The present study investigated the effects of rutin (RUT), which has various
biological and pharmacological properties, on liver and kidney damage caused by histone …
biological and pharmacological properties, on liver and kidney damage caused by histone …
Heavy metal pollution and risk assessment by the battery of toxicity tests
The current study was carried out on dominant fish Oreochromis niloticus and water
collected from the polluted Yamuna River, Agra, India. The heavy metals in water, recorded …
collected from the polluted Yamuna River, Agra, India. The heavy metals in water, recorded …
[HTML][HTML] Bioaccumulation of heavy metals and their toxicity assessment in Mystus species
This study was conducted on two native fish species namely Mystus vittatus and Mystus
tengara inhabiting challenging environment of Yamuna River. The heavy metals …
tengara inhabiting challenging environment of Yamuna River. The heavy metals …
Syringic acid and silymarin concurrent administration inhibits sodium valproate‐induced liver injury in rats
Sodium valproate (SV) is a well‐known anti‐epileptic drug, also used to control convulsions,
bipolar disorders and migraines. SV has been shown to induce liver toxicity in clinical …
bipolar disorders and migraines. SV has been shown to induce liver toxicity in clinical …
The implication of LPS/TLR4 and FXR receptors in hepatoprotective efficacy of indole-3-acetic acid and chenodeoxycholic acid
AS Aljarboa, AM Alhusaini, WS Sarawi, R Mohammed… - Life Sciences, 2023 - Elsevier
Aim Valproic acid (VPA) belongs to the first-generation antiepileptic drugs, yet its prolonged
use can cause life-threatening liver damage. The importance of our study is to investigate …
use can cause life-threatening liver damage. The importance of our study is to investigate …
Protective effects of naringin on valproic acid-induced hepatotoxicity in rats
Valproic acid (VPA) is mainly prescribed to treat epilepsy. VPA has been reported to be
associated with many adverse effects, including hepatotoxicity. Naringin (NRG) is a natural …
associated with many adverse effects, including hepatotoxicity. Naringin (NRG) is a natural …
Labeo rohita, a bioindicator for water quality and associated biomarkers of heavy metal toxicity
This study investigated the effect of heavy metals on Labeo rohita inhabiting the Yamuna
River, India. Levels of heavy metals measured in the water were as follows: Fe> Mn> Zn> …
River, India. Levels of heavy metals measured in the water were as follows: Fe> Mn> Zn> …
Role of melatonin and quercetin as countermeasures to the mitochondrial dysfunction induced by titanium dioxide nanoparticles
Aim Due to the growing commercialization of titanium dioxide nanoparticles (TNPs), it is
necessary to use these particles in a manner that is safe, healthy and environmental friendly …
necessary to use these particles in a manner that is safe, healthy and environmental friendly …