CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …

COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of
physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly …

The success of checkpoint inhibitors has accelerated the clinical implementation of a vast
mosaic of single agents and combination immunotherapies. However, the lack of clinical …

The novel 2019 strain of coronavirus is a source of profound morbidity and mortality
worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high …

Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …

Infiltration, accumulation, and survival of chimeric antigen receptor T (CAR-T) cells in solid
tumors is crucial for tumor clearance. We engineered CAR-T cells to express interleukin (IL) …

Abstract Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT
('signal transducer and activator of transcription') family constitute a rapid membrane-to …

Recent evidence indicates that mitochondria lie at the heart of immunity. Mitochondrial DNA
acts as a danger-associated molecular pattern (DAMP), and the mitochondrial outer …

The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell
development, as well as differentiation and survival of naive T cells, and generation and …

Blocking Programmed Death–1 (PD-1) can reinvigorate exhausted CD8 T cells (TEX) and
improve control of chronic infections and cancer. However, whether blocking PD-1 can …