Breast cancer is associated with the second highest cancer-associated deaths worldwide.
Therefore, understanding the key events that determine breast cancer progression …

The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

The development of the mammary gland is unique: the final stages of development occur
postnatally at puberty under the influence of hormonal cues. Furthermore, during the life of …

The mammary epithelium is highly responsive to local and systemic signals, which
orchestrate morphogenesis of the ductal tree during puberty and pregnancy. Based on …

Many cancer patients suffer from metastatic relapse several years after they have undergone
radical surgery. Early cancer cell dissemination followed by a protracted period of dormancy …

Genome-wide association studies (GWAS) were successful to identify genetic factors
robustly associated with lung cancer. This review aims to synthesize the literature in this field …

Despite advances in our understanding of breast cancer, patients with metastatic disease
have poor prognoses. GATA3 is a transcription factor that specifies and maintains mammary …

The mammary epithelium comprises two primary cellular lineages, but the degree of
heterogeneity within these compartments and their lineage relationships during …

Introduction The organisation of the mammary epithelial hierarchy is poorly understood. Our
hypothesis is that the luminal cell compartment is more complex than initially described, and …

It is becoming increasingly clear that short and long noncoding RNAs critically participate in
the regulation of cell growth, differentiation, and (mis) function. However, while the functional …