Uveal melanoma metastasis

E Rossi, M Croce, F Reggiani, G Schinzari, M Ambrosio… - Cancers, 2021 - mdpi.com
Simple Summary Survival after diagnosis of metastatic uveal melanoma has not significantly
improved over decades, most patients die within a year from diagnosis. Uveal melanoma is …

Prognostic biomarkers in uveal melanoma: The status quo, recent advances and future directions

NJ Lamas, A Martel, S Nahon-Estève, S Goffinet… - Cancers, 2021 - mdpi.com
Simple Summary Although rare, uveal melanoma (UM) is the most common cancer that
develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal …

Cobalt and ruthenium complexes with pyrimidine based schiff base: Synthesis, characterization, anticancer activities and electrochemotherapy efficiency

ME Alkış, Ü Keleştemür, Y Alan, N Turan… - Journal of Molecular …, 2021 - Elsevier
In this study, a new Schiff base ligand and its two M (II) complexes [CoCl· L (H 2 O) 2]· 2H 2
O,[RuCl (p-cymene) L] were synthesized. The structural features were confirmed from their …

Assessment of ablation therapy in pancreatic cancer: the radiologist's challenge

V Granata, R Grassi, R Fusco, SV Setola… - Frontiers in …, 2020 - frontiersin.org
This article provides an overview of imaging assessment of ablated pancreatic cancer. Only
studies reporting radiological assessment on pancreatic ablated cancer were retained. We …

Uveal melanoma pathobiology: Metastasis to the liver

P Bustamante, L Piquet, S Landreville… - Seminars in cancer …, 2021 - Elsevier
Uveal melanoma (UM) is a type of intraocular tumor with a propensity to disseminate to the
liver. Despite the identification of the early driver mutations during the development of the …

The CAM assay as an alternative in vivo model for drug testing

R Schneider-Stock, D Ribatti - Organotypic Models in Drug Development, 2021 - Springer
In the last decade, the chicken chorioallantoic membrane (CAM) assay has been re-
discovered in cancer research to study the molecular mechanisms of anti-cancer drug …

Schiff base containing fluorouracil and its M (II) complexes: Synthesis, characterization, cytotoxic and antioxidant activities

A Savcı, N Turan, K Buldurun, ME Alkış… - Inorganic Chemistry …, 2022 - Elsevier
Abstract Herein, new Cu (II), Ru (II) and Pd (II) complexes including (2E, 2′ Z)-2, 2′-(1, 2-
phenylenebis (azan-1-yl-1-ylidene)) bis (5-fluoro-2, 3dihydropyrimidin-4 (1H)-one) Schiff …

New perspectives for eye-sparing treatment strategies in primary uveal melanoma

K Bilmin, KJ Synoradzki, AM Czarnecka, MJ Spałek… - Cancers, 2021 - mdpi.com
Simple Summary Uveal melanoma is the most common intraocular cancer. The current eye-
sparing treatment options include mostly plaque brachytherapy. However, the effectiveness …

The chorioallantoic membrane as a bio-barrier model for the evaluation of nanoscale drug delivery systems for tumour therapy

E Preis, J Schulze, B Gutberlet, SR Pinnapireddy… - Advanced drug delivery …, 2021 - Elsevier
Abstract In 2010, the European Parliament and the European Union adopted a directive on
the protection of animals used for scientific purposes. The directive aims to protect animals …

Calcium electroporation versus electrochemotherapy with bleomycin in an in vivo CAM-based uveal melanoma xenograft model

T Tsimpaki, R Anastasova, H Liu, B Seitz… - International Journal of …, 2024 - mdpi.com
Despite recent advancements in the diagnosis and treatment of uveal melanoma (UM), its
metastatic rate remains high and is accompanied by a highly dismal prognosis, constituting …